PhD in Molecular and Experimental Medicine

This 3-year international programme provides advanced training in various fields of life sciences and molecular medicine.

PhD MEM 2019-2020

Applications will be open from Monday April 29th  to June 20th  2019. 

For further information about the admission process please check the How to Apply section

 

Mission

The PhD Programme in Molecular and Experimental Medicine (MEM) aims to address some of the main challenges of life sciences in an high competitive scientific research environment.

The MEM PhD Programme provides training in various fields of life sciences and molecular medicine offering a stimulating environment with access to state-of-the-art technology and clinical case lists for translational studies.

Starting from academic year 2019-2020 two different curricula will be available; candidate are required to specify their curriculum preferences when applying.

The MEM curriculum provides for the research activities to develop along, yet not remain limited to, the following main areas, including: oncological immunopathology, molecular cardiometabolics, genetics, neurosciences. An overall vision of regenerative and precision medicine is the theme running throughout the programme. The curriculum provides specific training for enabling technologies, such as imaging, flow cytometry, genomics and bioinformatics.

The MEM-Clinical curriculum aims to combine basic or clinical experimental research activities with clinical practice involving patient enrolment and assessment in specific trials. The course provides for ordinary clinical practice in the hospital under the supervision of a doctor (up to a maximum of 20 hours per week) and experimental laboratory activities, which include but are not limited to cellular and molecular biology, information technology, immunology and the use of preclinical models. Candidates will be directly responsible for research projects approved by their clinical supervisor and/or laboratory head.

For both curricula the PhD will be conducted in a stimulating environment involving the organisation of Journal clubs and seminars given by national and international speakers, participation in congresses, informal meetings between different disciplines, encouraging researchers to work independently and collaboration with groups abroad. Liaising with tutors and non-Italian discussants further develops the international dimension.

 

Language: English
Duration: 3 years
Beginning of the academic year: November 1st, 2019

Future perspectives for Humanitas PhD students

The PhD program aims to train experts in clinical and industrial research, preparing them to take up careers in biotech companies, in translational research, in clinical or academic fields worldwide. Thanks to a “translational” approach, professionals will quickly transfer new knowledge from basic sciences to bio-medicine with the aim of creating new and advanced diagnostic and therapeutic applications.

Admission Requirements

MEM curriculum

Applicants wishing to enrol on the PhD course in Molecular and Experimental Medicine, MEM Curriculum must either have a “laurea magistrale” awarded in accordance with D.M. 270/2004 or equivalent qualification awarded by a foreign university (usually referred to as a Master’s Degree), in one of the subjects listed in the official call for applicants.

Applicants who are waiting to be awarded the required qualification at the date of submission can also take part in the selection process providing they have passed all of the Degree course exams at the time of the online application and are awarded the qualification by the final deadline of September 13th 2019. In the event these applicants pass the selection process, their enrolment on the PhD course is conditional upon providing proof that the qualification is awarded by September 16th 2019.

 

MEM-Clinical curriculum

Applicants wishing to enrol on the PhD Course in Molecular and Experimental Medicine, MEM-Clinical Curriculum must:

  • be enrolled on the Medical Register;
  • already possess a specialist medical qualification;

– Alternatively, applications will also be taken from doctors in specialist training who will enrol in the final year in a School of Specialisation at Humanitas University;

– Doctors in specialist training who are already enrolled in the final year of Specialisation at any university and who will complete their training by October 31st 2019 may also apply. In the event these applicants pass the selection process, they may conditionally enrol on the PhD Course and are required to provide proof that the qualification is awarded by  November 4th 2019.

How to Apply

  • Registration or access with your LOGINMIUR credentials
  • Application form submission
  • Payment of the application contribution

The application form must be completed in all its parts, on penalty of exclusion. In particular, applicants must submit all of the following documents in PDF format:

  1. Curriculum vitae
  2. Motivation letter
  3. Copy of a valid ID or passport (for Non-EU citizens)
  4. Diploma Supplement
  5. Copy of the receipt of payment of € 30,00

Additionally, applicants may indicate name and contacts of maximum two referees, preferably chosen among those who have had a supervising role of the candidates. The referees will be directly contacted by Humanitas University and asked to complete a brief letter of reference.

Further details about the application procedure will be reported in the official call for applicants.

 

APPLY

 

Admission process

Admission to the PhD Programme is based on a public selection process consisting of

  • the comparative evaluation of the titles and qualifications and
  • an interview carried out in English by a Committee composed of a maximum of seven members.

The aim of the selection process is to assess the knowledge, competencies and aptitude of the applicants for scientific research as well as their motivation for undertaking the PhD programme.

Prior to the interview, applicants may be asked to take a multiple choice test, aimed at assessing the applicant’s specific knowledge in the fields of the research projects of the Campus.

A good knowledge of English is required and will be tested during the interview.

Should reasons justify it, the test and interview can be conducted via video-conference. Those who intend to conduct the interview via video-conference or request special assistance should specify this on the application form.

The final ranking list will be posted on this page in the week starting on September 16th 2019.

Academic Board

PhD Coordinator: Professor Maria Rescigno

2019-2020 available positions and topics

There are 8 positions available. 
Additional places and/or scholarships may become available based on external fundings.

The number of available places and/or scholarships may increase in the event that external funding for additional places or scholarships becomes available by the deadline set for the completion of the call application procedure.

 

Research topics

Proposed research topics are listed below; go to the Research Topics section” to read the abstract, the main technical approaches and the scientific references of the project.

NTopic typeClinical SupervisorPre-clinical SupervisorLaboratory nameMain field of interestProject title
1MEM-ClinicoGiulio StefaniniGiulio StefaniniCardiovascular Department, Humanitas Research HospitalIschemic heart diseaseTherapeutic impact of autophagy activation on cardiac remodeling and cardiovascular damage after acute myocardial ischemia
2MEM-ClinicoFrancesca Puggioni
Enrico Marco HefflerPersonalized Medicine, Asthma and AllergyMolecular diagnosis in asthma and allergy; severe Asthma; asthma management; adherence to treatment; asthma control
Electronic referral based hub & spoke network model for the management of severe asthma
3MEM-ClinicoMatteo DonadonAna Lleo De NaldaDepartment Hepatobiliary and General Surgery
Humanitas University, Humanitas Clinical and Research Center IRCCS
Via Manzoni 56, 20089, Rozzano, Milano
Tumor microenviroment; tumor-associated immune cells; oncology; colorectal liver metastasesDevelopment of a new diagnostic tool based on tumor-associated macrophages to refine the prognosis of patients undergoing hepatic resection for colorectal liver metastases: a prospective study.
4MEM-ClinicoMatteo Simonelli
Raffaella BonecchiMedical Oncology Unit, Humanitas Cancer CenterNeuro-oncology, phase I clinical trials, translational immunologyProspective and comprehensive analysis of circulating and infiltrating leukocyte subsets in patients with diffuse malignant gliomas
5MEM-ClinicoArmando Santoro
Maria Rescigno
Humanitas Cancer Center
Medical Oncology and Hematology Unit
Via A. Manzoni 56
20089 Rozzano (MI)
Predictive factors of pathological complete response to neoadjuvant chemotherapy in breast cancer patients by radiomics, ICD and microbiotaAnalysis of combined assessment of metabolic radiomics pattern in [18]F-FDG-PET/CT, Immunogenic Cell Death induction and microbiota in the prediction of response to neoadjuvant chemotherapy in breast cancer patients: a proof-of-concept study
6MEM-ClinicoElizaveta Kon

Antonio SicaRegenerative Orthopedics, Rheumatology, Molecular Immunology
Knee osteoarthritisRole of the adipokine visfatin in inflammation and metabolic syndromes
7MEM-ClinicoEduardo Nobile-OrazioMichela MatteoliPathogenesis and therapy of Immune mediated neuropathiesPathogenesis and therapy of Immune mediated neuropathiesAnti-nerve reactivity as predictor of response to immune therapy in patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP): A proof of concept study with rituximab in patients with CIDP not responding to conventional immune therapy
8MEM-Maria RescignoMucosal Immunology and Microbiota Unit
Campus BDG C
Microbiota and the immune system in the gut in health and diseaseUse of superadsorbent hydrogels to protect the intestinal barrier to prevent or treat disorders in the gut-liver axis
9MEM-Jaillon Sebastien
Laboratory of experimental immunopathology
Humanitas University
Via Rita Levi Montalcini
20090 Pieve Emanuele (Italy)
Innate Immunity, Cancer, Cancer therapy, Inflammation, Neutrophils, unconventional T cellsExploring the role of neutrophils and unconventional T cells in antitumor immunity.
10MEM-Raffaella Bonecchi
Laboratory of leukocyte biology
Humanitas clinical and research center
Via Rita Levi Montalcini 4, 20090 Pieve Emanuele (Mi), Italy
Inflammation and cancerRole of the atypical chemokine receptor ACKR2 in colon cancer metastasis
11MEM-Stefania VetranoDepartment of Hepatobiliary and General Surgery
& Unit of Clinical and Experimental Immunology
Humanitas Clinical and Research Center – IRCCS
Via Manzoni 56, 20089, Rozzano, Milan
Role of Natural Killer cells in Primary Biliary CholangitisAt the borders between immune tolerance and autoimmunity: disclosing the mechanisms boosting the expansion of auto-reactive Natural Killer cells in Primary Biliary Cholangitis
12MEM-Dr Cristina SobacchiHuman Genome and Biomedical TechnologiesPhysiopathology of the bone tissueDissecting the neglected link between RANKL cytokine and stemness features with high relevance in osteoporosis
13MEM-Gioacchino NatoliTranscription and Chromatin
Humanitas University
Humanitas Clinical Research Center
Via Manzoni 56
20089 Rozzano, Milano
Italy
Transcriptional regulation and genomicsAn integrative genomic approach to understand the transcriptional bases of intratumoral heterogeneity in human PDACs
14MEM-Gioacchino NatoliTranscription and Chromatin
Humanitas University
Humanitas Clinical Research Center
Via Manzoni 56
20089 Rozzano, Milano
Italy
Transcriptional regulation and genomicsCharacterization of transcriptional and epigenetic regulators of macrophage activation
15MEM-Michela MatteoliPharmacology and Brain PathologySynaptic physiology and pharmacologyRole of microglial phagocytosis and autophagy in neuroprotection
16MEM-Raffaella Bonecchi
Laboratory of leukocyte biology
Humanitas clinical and research center
Via Rita Levi Montalcini 4, 20090 Pieve Emanuele (Mi), Italy
Inflammation and cancerRole of ACKR2 in trafficking and activation of anti-metastatic innate immunity
17MEM-Giulia SoldàMedical Genetics and RNA Biology
Building C
Humanitas University
Via Rita Levi Montalcini, 4
20090, Pieve Emanuele (Milano), Italy
Identification of prostate cancer biomarkersLiquid biopsy of semen for early detection and characterization of prostate cancer
18MEM-Stefania VetranoLaboratory of Gastrointestinal
Immunopathology
Eziopathogenesis of Inflammatory Bowel Diseases; link between Inflammation, diet and colorectal cancer
The impact of the diet in modulating IBD and CRC development
19MEM-Barbara BottazziLab of Immunopharmacology, Istituto Clinico Humanitas, Via Manzoni, 113- 20089 RozzanoInflammation & cancerCharacteriztion of the biochemical and biological properties of a novel molecule associated to M2 polarization of macrophages.
20MEM-Barbara BottazziLab of Immunopharmacology, Istituto Clinico Humanitas,
Via Manzoni, 113- 20089 Rozzano
Inflammation & cancerRole of molecules associated to M2 polarization of macrophages in cancer progression
21MEM-Diletta Di MitriTumor Microenvironment Unit
Humanitas Clinical and Research Center
Campus, Building C
Via Rita Levi Montalcini, 4
20090 Pieve Emanuele, Milan
Tumor immunology applied to prostate cancerInvestigation of the immune-associated mechanisms that modulate response to therapy in prostatic cancer
22MEM-Diletta Di MitriTumor Microenvironment Unit
Humanitas Clinical and Research Center
Campus, Building C
Via Rita Levi Montalcini, 4
20090 Pieve Emanuele, Milan
Tumor immunology applied to prostate cancerInvestigation of the mechanisms that drive the re-education of the innate immune response in in advanced prostate cancer
23MEM-Elisabetta MennaLaboratory of Pharmacology and Brain Pathology. Fondazione Humanitas per la Ricerca Via Manzoni 113 - 20089 Rozzano and Istituto di Neuroscienze del CNR, via Vanvitelli 32 Milano .
elisabetta.menna@in.cnr.it
Elisabetta.Menna@humanitasresearch.it
NeuroscienceRole of the SNARE protein, SNAP25, and PTX3 in aging.
24MEM-Enrico LugliLab of Translational Immunology, Hunimed Campus bldg. A, via Montalcini, Pieve EmanueleImmunology, cancer, single cell profiling, T cell differentiationCellular immune responses against human cancer
25MEM-Stefano DugaMedical Genetics and RNA BiologyMolecular genetics of human diseasesMolecular and cellular mechanism modulating GBA mutation penetrance in Parkinson’s disease

Scholarships and fees

The gross annual amount of each scholarship awarded by the University is € 18.000,00 for the MEM curriculum and € 22.400,00 for the MEM-Clinical curriculum, paid in monthly instalments.

PhD students are required to pay an annual fee for access and attendance, set at € 250,00 for the academic year 2019/2020, including the regional tax and stamp duty.

 

Why
Humanitas
University?
An Established Institution

An Established Institution
Humanitas is a renowned healthcare institution that has offered Medical Degrees for well over a decade as a partner of the University of Milan.

An International Career

An International Career
Join our international medical community where classes are taught in English by experienced professors and medical doctors from around the world. Your degree will allow you to work as a MD in the EU and abroad.

Clinical Experience

Clinical Experience
Direct clinical experience is supported by a solid tutoring system and starts in your third year, which gives you considerable practical experience.

Innovative and Active Teaching

Innovative and Active Teaching
Humanitas curriculum is enhanced by a wide variety of active learning methods based on a student-centred approach (Problem-Based Learning, Case method, Concept maps, Simulated patients).

Milano and Italy

Milano and Italy
Enjoy the style, culture, gastronomy and entertainment of one of Europe's most exciting cities. Venture further to experience the delights of Italy or use the opportunity to learn Italian.

Advanced Research and Technology

Advanced Research and Technology
Humanitas can count on state-of-the-art technologies and research experience. A new simulation centre of 1000 sm, designed according to the highest technological standards, will be ready for autumn 2017.

Contact Us

Contact
Humanitas University
Via Rita Levi Montalcini 4,
Pieve Emanuele 20090 Milan, Italy

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By public transport

Go straight on from Porta Ticinese, to Corso San Gottardo, to via Meda, via Montegani, and via dei Missaglia, then follow the signs for Istituto Clinico Humanitas, or Basiglio Milano 3.