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Assistant Professor General Pathology MED/04
Tumour cell biology: Epidemiology of cancer; Characteristics of benign and malignant tumors; Molecular basis of cancer; Evasion of immune destruction, Clinical aspect of patients with tumors.
Immunopathology: Hypersensitivity reactions; Autoimmune diseases; Immunodeficiency syndromes, Immunopathology
I obtained a PhD in immunology in 2007 (French Institute of Health and Medical Research (INSERM-Unit 564, University of Angers, France). Since January 2016, I am Assistant Professor at the Humanitas University, Pieve Emanuele, Milan, Italy. My research activity is focused on the cellular and molecular mechanisms involved in innate immunity and inflammation and their role in cancer. My expertise and leadership in the fields of neutrophil biology, immunology, immunopathology and cancer can be underlined by primary research articles and review articles published in prime journals (e.g. Cell, Nature, Immunity, J Exp Med, Nat Rev Immunol, Blood).
Scientific and Research Interests
Innate immunity, inflammation, neutrophils, antitumor immune response.
In particular, the focus of my research is the identification of the role of neutrophils in cancer and the investigation of the cross-talk between neutrophils and other leukocytes, including innate-like T cells. Our group is also interested in studying the role of neutrophils and innate-like T cells in antitumor therapy efficacy and in their clinical significance in patients. We revealed the occurrence and clinical significance of tumor associated neutrophils (TANs) in colorectal cancer (Galdiero et al., Int J Cancer. 2016). Recently, we identified a tripartite interaction involving neutrophils, macrophages and a subset of unconventional T cells essential for mounting an effective antitumor immune response in selected tumors (Ponzetta et al. Cell, 2019).
- Neutrophils driving unconventional T cells mediate resistance against murine sarcomas and selected human tumors. Ponzetta A, Carriero R, Carnevale S, Barbagallo M, Molgora M, Perucchini C, Magrini E, Gianni F, Kunderfranco P, Polentarutti N, Pasqualini F, Di Marco S, Supino D, Peano C, Cananzi F, Colombo P, Pilotti S, Alomar SY, Bonavita E, Galdiero MR, Garlanda C, Mantovani A, Jaillon S. Cell. 2019. Jul 11;178(2):346-360. IF= 36.2
- Occurrence and significance of tumor-associated neutrophils in patients with colorectal cancer. Galdiero MR, Bianchi P, Grizzi F, Di Caro G, Basso G, Ponzetta A, Bonavita E, Barbagallo M, Tartari S, Polentarutti N, Malesci A, Marone G, Roncalli M, Laghi L, Garlanda C, Mantovani A, Jaillon S. Int J Cancer. 2016 Jul 15;139(2):446-56. IF= 5
- PTX3 is an extrinsic oncosuppressor regulating complement-dependent inflammation in cancer. Bonavita E, Gentile S, Rubino M, Maina V, Papait R, Kunderfranco P, Greco C, Feruglio F, Molgora M, Laface I, Tartari S, Doni A, Pasqualini F, Barbati E, Basso G, Galdiero M.R, Nebuloni M, Roncalli M, Colombo, P., Laghi, L., Lambris J.D, Jaillon S, Garlanda C, Mantovani A. Cell. 2015. Feb; 160(4):700-14.
- The humoral pattern recognition molecule PTX3 is a key component of innate immunity against urinary tract infection. Jaillon S*, Moalli F, Ragnarsdottir B, Bonavita E, Riva F, Barbati E, Nebuloni M, Krajinovic LC, Markotic A, Valentino S, Doni A, Tartari S, Graziani G, Montanelli A, Delneste Y, Svanborg C, Garlanda C, Mantovani A*. Immunity. 2014 Apr; 40(4):621-32. * Corresponding authors. IF= 21.5
- Neutrophils in the activation and regulation of innate and adaptive immunity. Mantovani A, Cassatella MA, Costantini C, Jaillon S. Nat Rev Immunol.2011 Jul;11(8):519-31.IF= 44