At the Humanitas Centre for Knee Joint Reconstruction, the first personalized, 3D implantation of a total knee...
Experimental Medicine and Physiopathology
Researcher at Humanitas Research Center, Laboratory of Leukocyte Biology.
Education and Academic Background
Raffaella Bonecchi received her degree in biological sciences in 1996 from the University of Milan. Since then she has been working on chemokines and chemokine receptors, first at the Department of Immunology and Cell Biology at the Mario Negri Institute, from 2000 to 2015 at University of Milan, as an assistant professor and since 2016 at Humanitas University as associate professor. She initially focused on the differential expression of chemokine receptors by T-helper-cell subsets and dendritic cells. More recently, her research efforts have been concentrated on the characterization of the chemokine decoy receptor D6 and on the role of this receptor on tumor biology focusing in particular on the role of cells of innate immunity.
Scientific and Research Interests
Innate immunity; Inflammation and cancer; Monocytes and macrophages; Chemokine and chemokine receptors; Atypical or decoy chemokine receptor.
- Bonecchi, R., G. Bianchi, P. P. Bordignon, D. D’Ambrosio, R. Lang, A. Borsatti, S. Sozzani, P. Allavena, P. A. Gray, A. Mantovani, and F. Sinigaglia. Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s. J Exp Med 187:129-134.
- Mantovani, A., R. Bonecchi, and M. Locati. Tuning inflammation and immunity by chemokine sequestration: decoys and more. Nat Rev Immunol 6:907-918.
- Bonecchi, R., E. M. Borroni, A. Anselmo, A. Doni, B. Savino, M. Mirolo, M. Fabbri, V. R. Jala, B. Haribabu, A. Mantovani, and M. Locati. Regulation of D6 chemokine scavenging activity by ligand- and Rab11-dependent surface up-regulation. Blood 112:493-503.
- Savino, B., M. G. Castor, N. Caronni, A. Sarukhan, A. Anselmo, C. Buracchi, F. Benvenuti, V. Pinho, M. M. Teixeira, A. Mantovani, M. Locati, and R. Bonecchi. Control of murine Ly6C(high) monocyte traffic and immunosuppressive activities by atypical chemokine receptor D6. Blood 119:5250-5260
- Savino, B., N. Caronni, A. Anselmo, F. Pasqualini, E. M. Borroni, G. Basso, G. Celesti, L. Laghi, A. Tourlaki, V. Boneschi, L. Brambilla, M. Nebuloni, G. Vago, A. Mantovani, M. Locati, and R. Bonecchi. ERK-dependent downregulation of the atypical chemokine receptor D6 drives tumor aggressiveness in Kaposi sarcoma. Cancer Immunol Res 2:679-689.
2015 AIRC Investigator Grant: “Role of the atypical chemokine receptor ACKR2 in tumor progression”
2015 CARIPLO Biomedical science for young scientists: “The roles of the epigenetic genes Uhrf1 and Ezh2 in neointima formation and the inflammatory response during atherosclerosis development”