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Nicoletta Di Simone

Full Professor

Obstetrics and Gynaecology

Full Professor of Obstetrics and Gynaecology, Humanitas University; Director of Postgraduate School Gynecology and Obstetrics, Humanitas University Milan.

E-mail

nicoletta.disimone@hunimed.eu

Education

1988 Graduated in Medicine, Catholic University of Rome, Rome, Italy.
1992 Completed residency in Obstetrics and Gynaecology, Catholic University of Rome (UCSC), Italy.
1994-1996 Fellowship at the National Center for Infertility Research at Massachusetts General Hospital-Harvard Medical School, Boston, USA.

Academic Honors:

2001 Visiting Professor, Prenatal Medicine Research Unit, Universitats Frauenklinik, Kantosspital, Basel, Switzerland
2008 Elected Member of the Society of Reproductive Investigation (SRI)
2019 Elected Member of the Board of Directors of the Vatican Foundation, International Scientific Institute (ISI) Paolo VI.
2021 Full Professor of Gynecology and Obstetrics, Humanitas University Milan.
2021 Director of Postgraduate School of Gynecology and Obstetrics, Humanitas University Milan.

The research activity developed has made it possible to understand numerous causes that lead to obstetric failure (lack of conception, recurrent miscarriages, premature childbirth and the maternal complications) with an improvement of treatment.

List of the main themes developed:

Recurrent pregnancy loss from immunological causes and therapy.
The role of coeliac disease in women’s health issues and its association with obstetric complications.
Endometrial inflammation and female issues.
Causes of preeclampsia and predictive markers of pathology.
The protective role that a regular gut functionality ‘/permeability’ plays on female life.
The use of the microbiota as a diagnostic and therapeutic tool for women.

Recent Insights on the Maternal Microbiota: Impact on Pregnancy Outcomes. N. Di Simone, A. Santamaria Ortiz, M. Specchia, C. Tersigni, P. Villa, A. Gasbarrini, G. Scambia, S. D’ Ippolito. Front Immunol. 2020 Oct 23;11:528202. doi: 10.3389/fimmu.2020.528202. eCollection 2020
Synthetic PreImplantation Factor (sPIF) reduces inflammation and prevents preterm birth. Spinelli M, Boucard C, Di Nicuolo F, Haesler V, Castellani R, Pontecorvi A, Scambia G, Granieri C, Barnea ER, Surbek D, Mueller M, N. Di Simone, PLoS One. 2020 Jun 8;15(6):e0232493. doi: 10.1371/journal.pone.0232493. eCollection 2020.
Helicobacter pylori infection contributes to placental impairment in preeclampsia: basic and clinical evidences. N. Di Simone, Tersigni C, Cardaropoli S, Franceschi F, Di Nicuolo F, Castellani R, Bugli F, de Waure C, Cavaliere AF, Gasbarrini A, Sanguinetti M, Scambia G, Todros T. Helicobacter. 2017 Apr;22(2). doi: 10.1111/hel.12347. Epub 2016 Aug 3.
4. Human leukocyte antigen (HLA) DQ2/DQ8 prevalence in recurrent pregnancy loss women. D’ Ippolito S, Gasbarrini A, Castellani R, Rocchetti S, Sisti LG, Scambia G, N. Di Simone, Autoimmun Rev. 2016 Jul;15(7):638-43. doi: 10.1016/j.autrev.2016.02.009. Epub 2016 Feb 13.
Inflammosome in the human endometrium:further step in the evaluation of the “maternal side”. D’Ippolito S, Tersigni C, Marana R, Di Nicuolo F, Gaglione R, Rossi ED, Castellani R, Scambia G, N. Di Simone, Fertil Steril. 2016 Jan;105(1):111-8.e1-4. doi: 10.1016/j.fertnstert.2015.09.027. Epub 2015 Oct 30.