Associate Professor of Medical Genetics at Humanitas University since its opening. Rosanna Asselta graduated in Biology and received her PhD in Molecular Genetics Applied to Medical Sciences at the University of Milan. In 2005, she became Assistant Professor in Molecular Biology at the Faculty of Medicine at the University of Milan. Over the years, Prof. Asselta acquired a strong expertise in statistical analysis of genetic data, thanks to her experience of two years in the Department of Molecular Medicine University of Helsinki and at the “Broad Institute of Harvard and MIT” of Boston. During her doctorate, and then in the post-doctoral program, she was able to complete her training following courses at the Turku Centre for Biotechnology (2004), the European School of Genetic Medicine (2005), Helsinki University (2006), Cold Spring Harbor Laboratory (2008), and the Dana Farber Cancer Institute (2009). Prof. Asselta received prestigious awards from the Foundation Telethon (2001), the European Molecular Biology Organization (2004), and the European Science Foundation (2004). In 2005, the Early Career Investigator Award was also awarded (as part of the international program “Bayer Hemophilia program”). She is the author of 141 full papers indexed in PubMed, with an average impact factor greater than 8, and an h-index of 31 (WOS), 31 (Scopus), and 38 (Google Scholar).
The scientific work of Prof. Rosanna Asselta has focused on the study of genetic and molecular basis of human hereditary diseases both monogenic that multifactorial.
Prof. Asselta has dedicated the past five years to the study of:
- molecular mechanisms responsible for certain rare hemorrhagic coagulopathies (afibrinogenemia, congenital deficiency of coagulation factor V and XI).
- Study of the genetic determinants of susceptibility to some complex diseases (myocardial infarction youth, multiple sclerosis and Parkinson’s disease).
- Cardamone G, Paraboschi EM, Soldà G, Cantoni C, Supino D, Piccio L, Duga S, Asselta R. Not only cancer: the long non-coding RNA MALAT1 affects the repertoire of alternatively spliced transcripts and circular RNAs in multiple sclerosis. Hum Mol Genet. 2019;28:1414-1428.
- Asselta R, Paraboschi EM, Rimoldi V, Menegatti M, Peyvandi F, Salomon O, Duga S. Exploring the global landscape of genetic variation in coagulation factor XI deficiency. Blood. 2017;130:e1-e6.
- Asselta R, Rimoldi V, Siri C, Cilia R, Guella I, Tesei S, Soldà G, Pezzoli G, Duga S, Goldwurm S. Glucocerebrosidase mutations in primary parkinsonism. Parkinsonism Relat Disord. 2014;20:1215-20
- Do R, Stitziel NO, Won HH, Jørgensen AB, Duga S, Angelica Merlini P, Kiezun A, Farrall M, Goel A, Zuk O, Guella I, Asselta R, Lange LA, Peloso GM, Auer PL; NHLBI Exome Sequencing Project, Girelli D, Martinelli N, Farlow DN, DePristo MA, Roberts R, Stewart AF, Saleheen D, Danesh J, Epstein SE, Sivapalaratnam S, Kees Hovingh G, Kastelein JJ, Samani NJ, Schunkert H, Erdmann J, Shah SH, Kraus WE, Davies R, Nikpay M, Johansen CT, Wang J, Hegele RA, Hechter E, Marz W, Kleber ME, Huang J, Johnson AD, Li M, Burke GL, Gross M, Liu Y, Assimes TL, Heiss G, Lange EM, Folsom AR, Taylor HA, Olivieri O, Hamsten A, Clarke R, Reilly DF, Yin W, Rivas MA, Donnelly P, Rossouw JE, Psaty BM, Herrington DM, Wilson JG, Rich SS, Bamshad MJ, Tracy RP, Adrienne Cupples L, Rader DJ, Reilly MP, Spertus JA, Cresci S, Hartiala J, Wilson Tang WH, Hazen SL, Allayee H, Reiner AP, Carlson CS, Kooperberg C, Jackson RD, Boerwinkle E, Lander ES, Schwartz SM, Siscovick DS, McPherson R, Tybjaerg-Hansen A, Abecasis GR, Watkins H, Nickerson DA, Ardissino D, Sunyaev SR, O’Donnell CJ, Altshuler D, Gabriel S, Kathiresan S. Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction. Nature. 2015;518:102-6.
- TG and HDL Working Group of the Exome Sequencing Project, National Heart, Lung, and Blood Institute, Crosby J, Peloso GM, Auer PL, Crosslin DR, Stitziel NO, Lange LA, Lu Y, Tang ZZ, Zhang H, Hindy G, Masca N, Stirrups K, Kanoni S, Do R, Jun G, Hu Y, Kang HM, Xue C, Goel A, Farrall M, Duga S, Merlini PA, Asselta R, Girelli D, Olivieri O, Martinelli N, Yin W, Reilly D, Speliotes E, Fox CS, Hveem K, Holmen OL, Nikpay M, Farlow DN, Assimes TL, Franceschini N, Robinson J, North KE, Martin LW, DePristo M, Gupta N, Escher SA, Jansson JH, Van Zuydam N, Palmer CN, Wareham N, Koch W, Meitinger T, Peters A, Lieb W, Erbel R, Konig IR, Kruppa J, Degenhardt F, Gottesman O, Bottinger EP, O’Donnell CJ, Psaty BM, Ballantyne CM, Abecasis G, Ordovas JM, Melander O, Watkins H, Orho-Melander M, Ardissino D, Loos RJ, McPherson R, Willer CJ, Erdmann J, Hall AS, Samani NJ, Deloukas P, Schunkert H, Wilson JG, Kooperberg C, Rich SS, Tracy RP, Lin DY, Altshuler D, Gabriel S, Nickerson DA, Jarvik GP, Cupples LA, Reiner AP, Boerwinkle E, Kathiresan S. Loss-of-function mutations in APOC3, triglycerides, and coronary disease. N Engl J Med. 2014;371:22-31.