Education
- 2005: PhD in Biotechnology Applied to Medical Sciences, Department of Medical Genetics, University of Milan, Italy
- 2001: Master’s degree in Biological Sciences (summa cum laude), Department of Structural and Functional Biology, University of Insubria, Varese, Italy
- 1999 – 2001: Graduate student, Department of Structural and Functional Biology, Varese, Italy
Academic Appointments
- 2017: Assistant Professor, Humanitas University HUNIMED, Milan, Italy
- 2015 – 2017: Basic and Clinical Pharmacology, School of Medicine, Humanitas University
- 2013 – 2017: Basic and Clinical Pharmacology, School of Nursing, Humanitas University
- 2013 – 2016: Research Scientist, Laboratory of Pharmacology and Brain Pathology, Humanitas Clinical and Research Center, Milan, Italy
- 2010 – 2012: Senior Post-doctoral Fellow, Neuropsychopharmacology Lab, Department of Neuroscience, DIBIT- San Raffaele Vita-Salute University, Milan, Italy
- 2009 – 2013: Basic and Clinical Pharmacology, School of Medicine, University of Milan
- 2009 – 2013: Basic and Clinical Pharmacology, Faculty of Biotechnology, San Raffaele Vita-Salute
- 2007 – 2010: Post-doctoral Fellow, Istituto Italiano di Tecnologia, Department of Neuroscience and Brain Technologies, Genova, Italy
- 2002 – 2006: PhD Student, CNR – Istituto di Neuroscienze, Section of Molecular and Cellular Pharmacology, Milan, Italy
Other
- 2016: Organizer, International School of Neuroscience, Como
- 2015: Invited Speaker at Symposium en marge du Congrès des Neurosciences: “Intracellular Trafficking in Neurons”, Montpellier
Dr. Davide Pozzi’s research field is focused on basic neurobiology, with a specific interest on several aspects of synaptic function and structure, such as neurotransmission, synaptic plasticity and synaptogenesis. During his carrier he investigated the molecular mechanisms underlying the development and function of the presynaptic terminal, both at the structural and functional level. Moreover he also studied the molecular differences between glutamatergic and GABAergic synapses, identifying alternative role of presynaptic proteins specifically expressed at the inhibitory and excitatory terminals. Subsequently, he focused his attention on several aspects of synaptic plasticity, working on the clarification of the molecular determinants involved in homeostatic plasticity. In particular he unveiled a new role of the transcription factor REST/NRSF in the negative regulation of intrinsic excitability through the control of sodium channel gene expression during elevated neuronal activity. More recently he started investigating the contribution of immune molecules (i.e. cytokines) to brain homeostasis both in physiological and pathological states.
- Reduced SNAP-25 alters short term plasticity at developing glutamatergic synapses” Flavia Antonucci, Irene Corradini, Raffaella Morini, Giuliana Fossati, Elisabetta Menna, Davide Pozzi, Simone Pacioni, Claudia Verderio, Alberto Bacci and Michela Matteoli. EMBO Rep. 2013 Jul;14(7):645-51.
- “REST/NRSF-mediated intrinsic homeostasis protects neuronal networks from hyperexcitability” Pozzi D., Lignani G., Ferrea E., Contestabile A., Paonessa F., D’alessandro R., Lipiello P., Boido D., Meldolesi J., Valtorta F., Benfenati F., Baldelli P. EMBO J. 2013 Nov 13;32(22):2994-3007
- “Early defects in the development of Mecp2 null embryonic cortex precede the onset of overt RTT symptoms” Francesco Bedogni; Clementina Cobolli Gigli; Davide Pozzi; Riccardo L Rossi; Grazisa Rossetti; Linda Scaramuzza; Massimiliano Pagani; Michela Matteoli; Charlotte Kilstrup-Nielsen; Nicoletta Landsberger. Cereb Cortex. 2015 May
- “Ectonucleotidase activity and immunosuppression in astrocyte-CD4 T cell bidirectional signaling.” Filipello F, Pozzi D, Proietti M, Romagnani A, Mazzitelli S, Matteoli M, Verderio C, Grassi F. Oncotarget. 2016 Jan 13
- “Lack of IL-1R8 in neurons causes hyperactivation of IL-1 receptor pathway and induces MECP2-dependent synaptic defects” Romana Tomasoni, Raffaella Morini, Jose P. Lopez-Atalaya, Irene Corradini, Alice Canzi, Marco Rasile, Cristina Mantovani, Davide Pozzi, Cecilia Garlanda, Alberto Mantovani Elisabetta Menna, Angel Barco and Michela Matteoli. Elife. 2017 Mar 28;6