Maria Laura Costantino

The research activity is framed in the field of Industrial Bioengineering (both theoretical and experimental) focussing:

• Mass and energy transfer, and fluid dynamics in the biological system and artificial organs through both mathematical and numerical modelling, and experimental evaluation.
• Machine to patient interaction modelling.
• Patient-specific modelling, based on the structured analysis of clinical data, aimed at optimising the single patient reaction to the treatment.
• Design and experimental testing of biomedical devices (e.g. ventricular assist devices, dialysis filters and systems, blood oxygenators, pumping systems, heart valve prostheses, extracorporeal circuits components, liquid ventilation for pre-mature and neonates, etc.);
• Development of novel controlled drug release systems.

• Possenti, Luca, Casagrande, Giustina, Di Gregorio, Simone, Zunino, Paolo, Costantino, Maria Laura (2019). Numerical simulations of the microvascular fluid balance with a non-linear model of the lymphatic system. DOI:10.1016/j.mvr.2018.11.003. MICROVASCULAR RESEARCH, vol. 122, p. 101-110, ISSN: 0026-2862.
• Piergiovanni M., Casagrande G., Taverna F., Corridori I., Frigerio M., Bianchi E., Arienti F., Mazzocchi A., Dubini G., Costantino M. L. (2019). Shear-Induced Encapsulation into Red Blood Cells: A New Microfluidic Approach to Drug Delivery. DOI:10.1007/s10439-019-02342-w. ANNALS OF BIOMEDICAL ENGINEERING, vol. 2019 Aug 13, p. 1-11, ISSN: 0090-6964.
• Bianchi, Camilla, Lanzarone, Ettore, Casagrande, Giustina, Costantino, Maria Laura (2018). A Bayesian approach for the identification of patient-specific parameters in a dialysis kinetic model. DOI:10.1177/0962280217745572. STATISTICAL METHODS IN MEDICAL RESEARCH, p. 1-27, ISSN: 0962-2802.
• Luraghi, Giulia, Wu, Wei, De Gaetano, Francesco, Rodriguez Matas, Jose Felix, Moggridge, Geoff D., Serrani, Marta, Stasiak, Joanna, Costantino, Maria Laura, Migliavacca, Francesco (2017). Evaluation of an aortic valve prosthesis: Fluid-structure interaction or structural simulation? DOI:10.1016/j.jbiomech.2017.04.004. JOURNAL OF BIOMECHANICS, vol. 58, p. 45-51, ISSN: 0021-9290.
• Casagrande, Giustina, Bianchi, Camilla, Vito, Domenico, Carfagna, Fabio, Minoretti, Claudio, Pontoriero, Giuseppe, Rombolà, Giuseppe, Schoenholzer, Carlo, Costantino, Maria Laura (2016). Patient-specific modeling of multicompartmental fluid and mass exchange during dialysis. DOI:10.5301/ijao.5000504. INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS, vol. 39 (5), pp.220-227, ISSN:0391-3988.

• Member of the PhD in Bioengineering Board, at Politecnico di Milano.
• January 2013 to December 2018 Director of the Biomedical Engineering Programme Council at Politecnico di Milano, and member of the Board of the School of Industrial and Information Engineering at the same Politecnico.
• Since mid ’90s Director of the Artificial Organs Laboratory, part of the Biological Structures Mechanics (LaBS) Laboratory at Politecnico di Milano, coordinating research, consulting and teaching activities.