Alessandro Santini

My main interests of research are respiratory physiology, mechanical ventilation, acute respiratory distress syndrome, ventilator-induced lung injury and strategies to prevent it, ex-vivo solid organ (liver and lung) perfusion to evaluate marginal organs for transplantation.

During the years I have achieved a solid expertise in set-up and conduction of preclinical animal research on small animals (mice, rats) and large animals (swine) and in clinical trials design and conduction.

Protti A, Santini A, Pennati F, Chiurazzi C, Cressoni M, Ferrari M, Iapichino
GE, Carenzo L, Lanza E, Picardo G, Caironi P, Aliverti A, Cecconi M, Lung response to a higher positive end-expiratory pressure in mechanically ventilated patients with COVID-19, CHEST (2021), doi:https://doi.org/10.1016/j.chest.2021.10.012.

Santini A, Fumagalli J, Merrino A, Protti I, Paleari MC, Montoli M, Dondossola D, Gori F, Righi I, Rosso L, Gatti S, Pesenti A, Grasselli G, Zanella A. Evidence of Air Trapping During Ex Vivo Lung Perfusion: A Swine Experimental Lung Imaging and Mechanics Study. Transplant Proc. 2021; 53(1):457-465

Santini A, Mauri T, Dalla Corte F, Spinelli E, Pesenti A. Effects of inspiratory flow on lung stress, pendelluft and ventilation heterogeneity in ARDS: a physiological study. Crit Care 23, 369 (2019)

Langer T*, Santini A*, Zadek F, Chiodi M, Pugni P, Cordolcini V, Bonanomi B, Rosini F, Marcucci M, Valenza F, Marenghi C, Inglese S, Pesenti A, Gattinoni L. Intraoperative hypotension is not associated with postoperative cognitive dysfunction in elderly patients undergoing general anesthesia for surgery: results of a randomized controlled pilot trial. J Clin Anesth. 2019 Feb;52:111-118.* contributed equally to the study

Protti A, Cressoni M, Santini A, Langer T, Mietto C, Febres D, Chierichetti M, Coppola S, Conte G, Gatti S, Leopardi O, Masson S, Lombardi L, Lazzerini M, Rampoldi E, Cadringher P and Gattinoni L. Lung stress and strain during mechanical ventilation: Any safe threshold? Am J Respir Crit Care Med 2011;183:1354–1367