Education
- 2014: National Academic Qualification for the post of Associate Professor in Endocrinology; National Academic Qualification, Competition Sector 06D2 (Call for Applications 2013; Ministerial Decree No. 161/2013), valid from 1 December 2014 to 1 December 2020 (MIUR)
- 2012: Level II Master’s Degree in Osteoporosis and Bone Metabolic Diseases; Thesis: “Radiological vertebral fractures in elderly patients hospitalised with heart failure” University of Brescia
- 2005: Research Fellowship “Assessment of bone metabolism, bone mineral density, bone quality and vertebral deformities (non-clinical fractures) in patients with hypopituitarism and acromegaly”. Research and clinical work at the Osteoporosis Centre of the University of Brescia
- 2002 – 2003: Clinical Research Fellow at the “Autoimmunity Section” of the “Department of Medicine” at the University of Wales College of Medicine, Cardiff, Wales, UK. Research on animal models of thyroid autoimmunity and on clinical case series using sophisticated immunological analysis methods
- 2001 – 2004: PhD in “Pathology of Cellular Signal Transduction”, 16th cycle. Thesis written and defended in English: “IFN-alpha-related thyroid disease as a model of thyroid autoimmunity”; University of Campania Luigi Vanvitelli (formerly the Second University of Naples)
- 1995 – 2000: Specialisation in Endocrinology and Metabolic Diseases – specialising in Endocrinology – with a grade of 50/50 with Distinction; Thesis: “Prenylation inhibitors in the treatment of benign thyroid proliferation”; University of Campania Luigi Vanvitelli (formerly the Second University of Naples)
- 1996: Qualification to practise as a doctor and surgeon. Qualifying examination at the University of Campania Luigi Vanvitelli (formerly the Second University of Naples)
- 1995: Degree in Medicine and Surgery with a mark of 110/110 with Distinction; Thesis: “Thyroid autoimmunity in patients with chronic HCV-related infection”; University of Campania Luigi Vanvitelli (formerly the Second University of Naples)
Academic Appointments
- 2020 – present: Lecturer on the integrated course in Physiology, Anatomy and Biochemistry II (2nd year), MEDTEC School, Humanitas University and Politecnico di Milano.
- 2019 – present: Professor on the integrated course in System Diseases III (4th year), School of Medicine, Humanitas University.
- 2022: Director of the Level II Master’s Degree in the Management of Patients with Osteoporosis and Osteo-Metabolic Diseases, Humanitas University
- 2019: Appointed as Associate Professor in Endocrinology (MED/13) at the Department of Biomedical Sciences, Humanitas University, Milan.
- 2018: Successful candidate in the competition for a second-level professorship in Endocrinology (MED/13) at Humanitas University in Milan
Awards and Honors
- 2007: Italfarmaco National Award for Research into the therapeutic effects of somatostatin analogues, for a paper entitled “Effect of long-acting somatostatin analogue treatment on the PTH-vitamin D-calcium axis in acromegaly”.
- 2002: “Leonardo di Capua” Scholarship for Study abroad to Investigate the “triggering mechanisms and progression of autoimmune thyroiditis”.
Other
- 2019 – present: Head of the Centre for Research, Diagnosis and Treatment of Osteometabolic Diseases, part of the Department of Endocrinology, Diabetology and Medical Andrology, Humanitas Clinical Institute
- 2017 – 2019: Head of the ‘Endocrinology’ Unit, part of the General Medicine Department at the ‘C. Poma’ Hospital in Mantua.
- 2007 – 2019: Permanent Senior Consultant in Internal Medicine, on a permanent contract at the Department of Internal Medicine at the “C. Poma” Hospital in Mantua.
- 2013 – 2014: Secondment to the Chair of Endocrinology and the University Endocrinology Department at the Spedali Civili Hospital in Brescia
- 2005 – 2007: Permanent Level I Medical Director in Internal Medicine, on a permanent contract at the Internal Medicine Unit of the Ciriè Hospital, ASLTO6.
- 2005: Freelance on-call duty at the Complex Unit of Internal Medicine at the “C. Poma” Hospital in Mantua
- 2004 – 2005: Level I Medical Director in Internal Medicine, on a fixed-term contract at the Department of Medicine at the Palasciano Hospital in Capua (ASL/CE2).
Over the last 20 years, Gherardo Mazziotti has carried out seminal studies in the field of bone and mineral metabolism with significant contributions in the knowledge of mechanisms and clinical presentation of skeletal fragility induced by endocrine diseases and endocrine therapies in oncological patients.
Three of the main accomplishments of the researches in the bone field have been: 1) the application for the first time of vertebral morphometry for diagnosis of skeletal fragility in patients with osteoporosis related to endocrine disease; 2) the demonstration in humans that pituitary hormones (i.e., thyrotropin and prolactin) may have direct effects on bone and they may directly influence skeletal fragility; 3) impact of body composition on bone quality and fracture risk in subjects exposed to hormone deprivation therapies; 4) the application of artificial intelligence and telemedine in the therapeutic-decision making and management of patients with osteoporosis.
He was also leader author of studies on glucocorticoid-induced osteoporosis and multicenter studies in the oncology field investigating the management of bone metastases from thyroid cancer, the efficacy and safety of non conventional therapeutic schedules in acromegaly, the application of telemedicine in management of anti-osteoporotic therapies, application of artificial intelligence in prediction of fractures risk.
Gherardo Mazziotti has published more than 240 papers in international peer-reviewed journals (more than 12.000 citations, Scopus H-index 58; Scopus ID 6701486206).
- Birtolo MF, Levi R, Pagano M, Carrone F, Antonini S, Maida G, Savini G, Geroli F, Superbi S, Lania AG, Barbieri R, Mazziotti G, Politi LS. Artificial intelligence on opportunistic computed tomography for predicting vertebral fracture risk in women undergoing estrogen deprivation therapy for breast cancer. Radiol Med. 2026 Feb 11. doi: 10.1007/s11547-026-02172-6. Epub ahead of print. PMID: 41670884.
- Birtolo MF, Pedersini R, Palermo A, Vena W, Morenghi E, Cristofolini G, Presciuttini B, Tabacco G, Naciu AM, Pigni S, Laganà M, Mazzoleni F, Cosentini D, Ciafardini A, Pagani M, Farina D, Balzarini L, Zambelli A, Torrisi R, Cianferotti L, Napoli N, Bossi AC, Lania AG, Berruti A, Mazziotti G. Bone-active drugs in premenopausal women with breast cancer under hormone-deprivation therapies. Eur J Endocrinol. 2024 Aug 5;191(2):117-125. doi: 10.1093/ejendo/lvae086. PMID: 39056237.
- Cosentini D, Pedersini R, Di Mauro P, Zamparini M, Schivardi G, Rinaudo L, Di Meo N, Delbarba A, Cappelli C, Laganà M, Alberti A, Baronchelli M, Guerci G, Laini L, Grisanti S, Simoncini EL, Farina D, Mazziotti G, Berruti A; Bone Health Group of the ASST Spedali Civili, Brescia. Fat Body Mass and Vertebral Fracture Progression in Women With Breast Cancer. JAMA Netw Open. 2024 Jan 2;7(1):e2350950. doi: 10.1001/jamanetworkopen.2023.50950. Erratum in: JAMA Netw Open. 2024 Feb 5;7(2):e242491. doi: 10.1001/jamanetworkopen.2024.2491. PMID: 38198137; PMCID: PMC10782249.
- Biamonte E, Levi R, Carrone F, Vena W, Brunetti A, Battaglia M, Garoli F, Savini G, Riva M, Ortolina A, Tomei M, Angelotti G, Laino ME, Savevski V, Mollura M, Fornari M, Barbieri R, Lania AG, Grimaldi M, Politi LS, Mazziotti G. Artificial intelligence-based radiomics on computed tomography of lumbar spine in subjects with fragility vertebral fractures. J Endocrinol Invest. 2022 Oct;45(10):2007-2017. doi: 10.1007/s40618-022-01837-z. Epub 2022 Jun 25. PMID: 35751803.
- Mazziotti G, Lania AG, Canalis E. Skeletal disorders associated with the growth hormone-insulin-like growth factor 1 axis. Nat Rev Endocrinol. 2022 Jun;18(6):353-365. doi: 10.1038/s41574-022-00649-8. Epub 2022 Mar 14. PMID: 35288658.