Silvio Danese

Full Professor
Gastroenterology

Head of the Inflammatory Bowel Diseases Center at Humanitas Research Hospital
Group Leader of the Gastrointestinal Immunopathology Laboratory at Humanitas Research Center

Member, Italian Society of Gastroenterology (SIGE) and American Gastroenterology Association (AGA)
President – Elected, European Crohn’s and Colitis Organization (ECCO)
Secretary and Chair, Clinical trial task force of the International Organization of IBD (IOIBD).

Email silvio.danese@hunimed.eu
Phone +39 02 82244771
Site humanitas.net/en/doctors/danese-silvio; humanitas-research.org/gastrointestinal-immunopathology-teamsilviodanese.it

Education and Academic Background

Danese graduated at the Catholic University “Sacro Cuore” of Rome in 1999.

From 2001 to 2004, he moved to the Division of Gastroenterology – Case Western Reserve University -Cleveland, Ohio,US- where he worked as Research Associate in the field of Inflammatory Bowel Diseases (IBD), under the supervision of Prof. Claudio Fiocchi.

In 2004, Prof. Danese became specialist in Gastroenterology at the School of Specialization of the Policlinico Gemelli of Rome, leaded by Prof. G. Gasbarrini and at the same time he began the PhD/Doctor in Physiopathology of Metabolism, focusing specifically on basic and applied research concerning IBD.

Silvio Danese is now Full Professor of Gastroenterology at Humanitas University and head of the IBD center at the Humanitas Research Hospital.

He is currently working on several basic research projects and many phase I, II and III clinical trials for the treatment of IBD patients, in collaboration with numerous Italian, European and American centers.

He is also Member of the Editorial Board of “Current Drug Target” and “Alimentary Pharmacol & Therapeutics” and Associate Editor of “Gut” and “Journal of Crohn’s and Colitis”. He organizes and partecipates every year to numerous congresses, including ECCO, UEGW, DDW, FISMAD and he has published more than 300 research articles on peer-reviewed journal with high impact factor.

Teaching Appointments

  • From 2006 Prof. Danese teaches regularly classes at the students of Medicine. The classes are mainly based on Celiac Disease and Inflammatory Bowel Disease.
  • Since 2004 he has supervised the thesis of several medical and PhD students.
  • From July 2015 he is full Professor of Gastroenterology at Humanitas University .

Scientific and Research Interests

There are nearly 4 million people worldwide living with Inflammatory Bowel Diseases, namely Crohn’s disease and Ulcerative colitis, which in Italy affect approximately 200.000 persons. The development of new therapeutic approaches requires a better understanding of the molecular mechanism behind IBD pathogenesis.

Numerous are the research studies operating in Prof. Danese’s laboratory, some of which are developed in collaboration with national (IEO, IFOM, Policlinico Gemelli di Roma, Ospedale San Raffaele di Milano) and international (Chicago University, Notredame University, Cleveland University, Research Institute BSRC Athene) groups.

His research career is focused on the discovery of potential mechanisms involved in IBD and IBD-associated Colorectal Cancer pathogenesis, with a particular interest to leukocyte trafficking through both the blood and lymphatic intestinal endothelium.

He is investigating the role of lipid mediators in the resolution of intestinal inflammation, but he is also trying to understand the relationship between mucosal barrier integrity and microbiota in IBD, Colorectal Cancer and IBD-associated complications, such as Fibrosis.

 

Selected publications

  1. Tacconi C, Correale C, Gandelli A, Spinelli A, Dejana E, D’Alessio S, Danese S. Vascular endothelial growth factor C disrupts the endothelial lymphatic barrier to promote colorectal cancer invasion. 2015 Jun;148(7):1438-1451.
  2. D’Alessio S, Correale C, Tacconi C, Gandelli A, Pietrogrande G, Vetrano S, Genua M, Arena V, Spinelli A, Peyrin-Biroulet  L, Fiocchi C, Danese S. VEGF-C-dependent stimulation of lymphatic function ameliorates experimental inflammatory bowel disease. J Clinical Invest. 2014 Sep;124(9):3863-78.
  3. Correale C, Genua M, Vetrano S, Mazzini E, Martinoli C, Spinelli A, Arena V, Peyrin-Biroulet L, Caprioli F, Passini N, Panina-Bordignon P, Repici, Alberto Malesci A, Rutella S, Rescigno M, Danese S. The Bacterial Sensor Triggering Receptor Expressed on Myeloid Cells-2 Regulates the Mucosal Inflammatory Response. 2013 144:346-356.
  4. Danese S, Fiocchi C.Ulcerative colitis. N Engl J Med 2011 365:1713-25.
  5. Vetrano S, Borroni E. M, Sarukhan A, Savino B, Bonecchi R, Correale C, Arena V, Fantini M, Roncalli M, Malesi A, Mantovani A, Locati M, Danese S. The lympathic system control intestinal inflammation and inflammation-associated colon cancer thorugh the chemokine decoy receptor D6. Gut. 2010 Feb;59(2):197-206.

 

Academic Honors, Awards and Prizes

Honors

  • Designed Member of the Astra Zeneca program: ”Emerging Leaders in Gastroenterology”.
  • 2005. Designed Member for the ASNEMGE Program: ”Rising Star in Gastroenterology 2005”.
  • 2006. Designed Member of the Astra Zeneca program: ”Emerging Leaders Alumni in Gastroenterology”
  • 2011- 2015  Secretary of European Crohn’s and Colitis Organization
  • 2016-present President-Elect of European Crohn’s and Colitis Organization

Grants

  • 2000. Grant from the Italian Society of Gastroenterology (SIGE) for the project “Study of the activation state of platelets in inflammatory bowel disease”.
  • 2004. Grant from The Italian Society of Internal Medicine (SIMI) for the project: “Angiogenesis as a therapeutic strategy in animal models of inflammatory bowel disease”.
  • 2004. Grant from the AMICI foundation of Piemonte (Italian Crohn’s and Colitis Foundation) for the Project: “Angiogenesis in human inflammatory bowel disease”.
  • 2005. Grant from the Broad Medical Research Program for the project:” Angiogenesis in Inflammatory bowel disease: the contribution of platelet-endothelial interactions and implications for novel therapeutic approaches”.
  • 2006. Grant from the European Community (FRP6) for the project: “Usefulness of a new DNA array (“IBDChip”) to predict clinical course, development of complications, and response to therapy in patients with inflammatory bowel disease (IBD)”.
  • 2007. IRCCS Grant Coordinator for the project: “The protein C pathway in IBD”
  • 2007. Grant from the Associazione Italiana Ricerca cancro (AIRC) for the project: “Evaluation of the role of activated platelets in colon cancer growth and angiogenesis”.
  • 2007. Grant from the Italian Society of Gastroenterology for the project: The role of VEGF-A in IBD.
  • 2008. Grant from the Broad Medical Research Program for the project: ”Lymphangiogenesis in Inflammatory bowel disease pathogenesis”.
  • 2008. Grant form the European Crohn’s and Colitis Organization for the project: The role of Lymphatic system in IBD pathogenesis”.
  • 2008. Grant from Fondazione Cariplo for the project: “Stem-cell-endothelial interactions in IBD”.
  • 2008. Grant from the Italian Ministery of Health for the project: “Manipulation of the lymphatic system as a novel approach for IBD treatment”.
  • 2009.  Grant from the the Associazione Italiana Ricerca cancro (AIRC) for the project: “The lymphatic system in colitis associated cancer”.
  • 2010. Grant from Fondazione Cariplo for the project: “The protein C system in IBD pathogenesis”.
  • 2011. Grant from European Community on Immune mediate diseases. Work package coordinator.
  • 2011. Grant from NIH for the project: “The lymphatic system in Inflammatory bowel disease”.
  • 2012. Grant from The Broad Foundation for the project: “The role of Triggered Receptor Expressed on Myeloid cell-2 (TREM-2) and intestinal flora in colon cancer development“.
  • 2013. Grant from AIRC for the project: “The role of Triggered Receptor Expressed on Myeloid cell-2 (TREM-2) and intestinal flora in colon cancer development”.
  • 2013. Grant from the Italian Ministery of Health  for the project: “New cellular and molecular mechanisms in Colitis-Associated Colorectal Cancer: implications for innovative therapeutic approaches”.
  • 2013. Grant from Italian Ministery of Health (FIRB-Futuro in Ricerca) for the project: “New cellular and molecular mechanisms in Colitis-Associated Colorectal Cancer: implications for innovative therapeutic approaches”.
  • 2016. Grant from AIRC for the project: “The role of TRPV-4 in the pathogenesis of Colorectal Cancer”
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