Raffaello Furlan

Full Professor
Internal Medicine

Director of the Post-graduate School of Internal Medicine, Humanitas University
Director of Clinica Medica – Medicina 4, Humanitas Research Hospital
President of the School of Physiotherapy, Humanitas University
Head of the “Syncope and Orthostatic Intolerance Disorders Unit”, Humanitas Research Hospital

Visiting Professor at Vanderbilt University (Nashville, TN – USA)

E-mail raffaello.furlan@hunimed.eu  raffaello.furlan@humanitas.it
Telephone +39 02 82247453, +390282247228

 

Education and Academic Background

Education

  • Medical Doctor, magna cum laude, 1979, University of Milan, Milan Italy
  • Post-graduate training:
    • Cardiology, 1981, University of Milan Medical School
    • Sport Medicine, 1984 University of Milan Medical School
    • Basic Life Support Instructor, 1998
    • Management of Public Health Service, 2001, I.Re.F

Academic Background

  • Non-Tenured Professor, post-graduate course of Clinical Psychology, University of Milan (1991-2003)
  • Associate Professor of Medicine University of Milan (2005) and Humanitas University (2016)
  • Full Professor of Internal Medicine, Director of the Post-graduate School of Internal Medicine and President of the School of Physiotherapy at Humanitas University

  • Visiting Professor at Vanderbilt University (Nashville, TN – USA)

Other Academic and Teaching appointments

  • Coordinator of the courses entitled “Patient Management” and “Emergency”, School of Medicine, Humanitas University
  • Coordinator of the course entitled “Emergency”, School of Nursing, Humanitas University
  • Coordinator of the course entitled “The Autonomic Nervous System as a Tool for Human Interaction with the Environment”, School of Physiotherapy, Humanitas University

Scientific and Research Interests

Main contributions

Animal

From 1977 to 1984 he took part in studies aimed at evaluating: a. the role of vascular and cardiac sympathetic excitatory reflexes originating from the thoracic aorta and regulating systemic arterial pressure in conscious dogs (Clin Sci 1981;61:181s-183s. J Auton Nerv Syst 1983;7:295-301 ) and b. the neural mechanisms underlying cardiac pain and its potential hemodinamic effects in conscious animals (Circ Res 1985;56:175-183).

In conscious dogs it was therefore possible to describe for the first time:

Clinical

Since 1982, he took active part in the development of a novel high fidelity technique to record direct systemic and right ventricle blood pressures continuously up to 24 h in ambulant humans. He studied the changes in the neural mechanisms controlling human cardiovascular system during physiological and pathological conditions including the gravitational stimulus, physical exercise, mental stress and over 24 hours. The autonomic profile of disorders such as Pure Autonomic Failure (PAF), Ulcerative Colitis, Fibromyalgia and Parkinson’s disease were also studied. For these goals, power spectral and cross-spectral analyses of heart period and systolic blood pressure variability were used together with the direct recording of the post-ganglionic sympathetic nerve activity (Muscle Sympathetic Nerve Activity, MSNA).

Thereafter, he studied the neural changes preceding neuro-mediated syncope and the possible modifications of baroreceptor sensitivity in habitual fainters. In addition, he evaluated the pathophysiology of Chronic Orthostatic Intolerance (COI, or Postural Orthostatic Tachycardia Syndrome) and the changes in orthostatic tolerance following long term bed rest (ESA, European Space Agency project).

From 2004, Dr. Furlan leaded independent prospectic multicenter clinical studies aimed at evaluating the short and long term prognosis of patients presenting to the Emergency Department (ED) for syncope (STePS study, Short Term Prognosis of Syncope). He focused on the problems of syncope risk stratification and evaluated the suitability of the European Society of Cardiology syncope guide-lines in helping doctors in their decision making. More recently, he organized an International Consensus about priorities of clinical research on syncope and on syncope first clinical management.

 

Current research interests

[number of dissertations available (N=) for medical students and medical doctors specializing in Internal and Emergency Medicine]

  • Dynamics of pulmonary gas exchange and systemic oxygen delivery during exercise in patients affected by Postural Tachycardia Syndrome (POTS) and Hypertension (N=1).
  • Altered sympathetic response to gravitational stimulus after bed rest: mechanistic insights into orthostatic intolerance from MSNA (N=2).

 

Selected Publications

  1. Furlan R, Guzzetti S, Crivellaro W, Dassi S, Tinelli M, Baselli G, Cerutti S, Lombardi F, Pagani M, Malliani A. Continuous 24-hour assessment of the neural regulation of systemic arterial pressure and RR variabilities in ambulant subjects. Circulation 1990;81:537-547.
  2. Furlan R, Piazza S, Dell’Orto S, Barbic F, Bianchi A, Mainardi L, Cerutti S, Pagani M, Malliani A. Cardiac autonomic patterns preceding occasional vasovagal reactions in healthy humans. Circulation 1998;98:1756-1761.
  3. Furlan R, Jacob G, Snell M, Robertson D, Porta A, Harris P, Mosqueda-Garcia R. Chronic orthostatic intolerance: a disorder with discordant cardiac and vascular sympathetic control. Circulation  1998;98:2154-2159.
  4. Costantino G, Perego F, Dipaola F, Borella M, Galli A, Cantoni G, Dell’Orto S, Dassi S, Filardo N, Duca PG, Montano N, Furlan R. Short- and long-term prognosis of syncope, risk factors, and role of hospital admission: results from the STePS (Short-Term Prognosis of Syncope) study. J Am Coll Cardiol 2008;51:276-283.
  5. Costantino G, Sun BC, Barbic F, Bossi I, Casazza G, Dipaola F, McDermott D, Quinn J, Reed MJ, Sheldon RS, Solbiati M, Thiruganasambandamoorthy V, Beach D, Bodemer N, Brignole M, Casagranda I, Del RA, Duca P, Falavigna G, Grossman SA, Ippoliti R, Krahn AD, Montano N, Morillo CA, Olshansky B, Raj SR, Ruwald MH, Sarasin FP, Shen WK, Stiell I, Ungar A, Gert van DJ, van DN, Wieling W, Furlan R. Syncope clinical management in the emergency department: a consensus from the first international workshop on syncope risk stratification in the emergency department Eur Heart J 2016;37:1493-1498.

 

Academic honors

  • External Contributor to the EHRA (European Heart Rhythm Association of the European Society of Cardiology) Position Paper on “Syncope Unit. Rationale and requirements” Europace 2015;17:1325-1340)
  • Member of the Scientific Board of the 2018 ESC Guidelines for the diagnosis and management of syncope
Why
Humanitas
University?
An Established Institution

An Established Institution
Humanitas is a renowned healthcare institution that has offered Medical Degrees for well over a decade as a partner of the University of Milan.

An International Career

An International Career
Join our international medical community where classes are taught in English by experienced professors and medical doctors from around the world. Your degree will allow you to work as a MD in the EU and abroad.

Clinical Experience

Clinical Experience
Direct clinical experience is supported by a solid tutoring system and starts in your third year, which gives you considerable practical experience.

Innovative and Active Teaching

Innovative and Active Teaching
Humanitas curriculum is enhanced by a wide variety of active learning methods based on a student-centred approach (Problem-Based Learning, Case method, Concept maps, Simulated patients).

Milano and Italy

Milano and Italy
Enjoy the style, culture, gastronomy and entertainment of one of Europe's most exciting cities. Venture further to experience the delights of Italy or use the opportunity to learn Italian.

Advanced Research and Technology

Advanced Research and Technology
Humanitas can count on state-of-the-art technologies and research experience. A new simulation centre of 1000 sm, designed according to the highest technological standards, will be ready for autumn 2017.

Contact Us

Contact
Humanitas University
Via Rita Levi Montalcini 4,
Pieve Emanuele 20090 Milan, Italy

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