Raffaella Bonecchi

Associate professor
Experimental Medicine and Physiopathology

Researcher at Humanitas Research Center, Laboratory of Leukocyte Biology.

E-mail raffaella.bonecchi@hunimed.eu 
Phone: +39 02 82245117

 

Education and Academic Background

Raffaella Bonecchi received her degree in biological sciences in 1996 from the University of Milan. Since then she has been working on chemokines and chemokine receptors, first at the Department of Immunology and Cell Biology at the Mario Negri Institute, from 2000 to 2015 at University of Milan, as an assistant professor and since 2016 at Humanitas University as associate professor. She initially focused on the differential expression of chemokine receptors by T-helper-cell subsets and dendritic cells. More recently, her research efforts have been concentrated on the characterization of the chemokine decoy receptor D6 and on the role of this receptor on tumor biology focusing in particular on the role of cells of innate immunity.

Scientific and Research Interests

Innate immunity; Inflammation and cancer; Monocytes and macrophages; Chemokine and chemokine receptors; Atypical or decoy chemokine receptor.

 

Selected Publications

  1. Bonecchi, R., G. Bianchi, P. P. Bordignon, D. D’Ambrosio, R. Lang, A. Borsatti, S. Sozzani, P. Allavena, P. A. Gray, A. Mantovani, and F. Sinigaglia. Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s. J Exp Med 187:129-134.
  2. Mantovani, A., R. Bonecchi, and M. Locati. Tuning inflammation and immunity by chemokine sequestration: decoys and more. Nat Rev Immunol 6:907-918.

  3. Bonecchi, R., E. M. Borroni, A. Anselmo, A. Doni, B. Savino, M. Mirolo, M. Fabbri, V. R. Jala, B. Haribabu, A. Mantovani, and M. Locati. Regulation of D6 chemokine scavenging activity by ligand- and Rab11-dependent surface up-regulation. Blood 112:493-503.
  4. Savino, B., M. G. Castor, N. Caronni, A. Sarukhan, A. Anselmo, C. Buracchi, F. Benvenuti, V. Pinho, M. M. Teixeira, A. Mantovani, M. Locati, and R. Bonecchi. Control of murine Ly6C(high) monocyte traffic and immunosuppressive activities by atypical chemokine receptor D6. Blood 119:5250-5260
  5. Savino, B., N. Caronni, A. Anselmo, F. Pasqualini, E. M. Borroni, G. Basso, G. Celesti, L. Laghi, A. Tourlaki, V. Boneschi, L. Brambilla, M. Nebuloni, G. Vago, A. Mantovani, M. Locati, and R. Bonecchi. ERK-dependent downregulation of the atypical chemokine receptor D6 drives tumor aggressiveness in Kaposi sarcoma. Cancer Immunol Res 2:679-689.

 

Grant

  • 2015 AIRC Investigator Grant: “Role of the atypical chemokine receptor ACKR2 in tumor progression”

    2015 CARIPLO Biomedical science for young scientists: “The roles of the epigenetic genes Uhrf1 and Ezh2 in neointima formation and the inflammatory response during atherosclerosis development”

Why
Humanitas
University?
An Established Institution

An Established Institution
Humanitas is a renowned healthcare institution that has offered Medical Degrees for well over a decade as a partner of the University of Milan.

An International Career

An International Career
Join our international medical community where classes are taught in English by experienced professors and medical doctors from around the world. Your degree will allow you to work as a MD in the EU and abroad.

Clinical Experience

Clinical Experience
Direct clinical experience is supported by a solid tutoring system and starts in your third year, which gives you considerable practical experience.

Innovative and Active Teaching

Innovative and Active Teaching
Humanitas curriculum is enhanced by a wide variety of active learning methods based on a student-centred approach (Problem-Based Learning, Case method, Concept maps, Simulated patients).

Milano and Italy

Milano and Italy
Enjoy the style, culture, gastronomy and entertainment of one of Europe's most exciting cities. Venture further to experience the delights of Italy or use the opportunity to learn Italian.

Advanced Research and Technology

Advanced Research and Technology
Humanitas can count on state-of-the-art technologies and research experience. A new simulation centre of 1000 sm, designed according to the highest technological standards, will be ready for autumn 2017.

Contact Us

Contact
Humanitas University
Via Rita Levi Montalcini 4,
Pieve Emanuele 20090 Milan, Italy

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