Michela Matteoli

Full Professor
Pharmacology

Director of Neurological Research Area and Head of Lab, Humanitas Clinical and Research Center; Director of the CNR Institute of Neuroscience

Email michela.matteoli@humanitasresearch.it
Site humanitas-research.org/category/principal-investigator/matteoli

Biosketch

M. Matteoli received her PhD from the University of Pisa in 1989. From 1989 to 1991 she has been a postdoctoral fellow at the Yale University School of Medicine and Visiting Scientist at the Virginia School of Medicine. In 1992 she established her laboratory at the CNR-Center of Molecular and Cellular Pharmacology. In 2002 she became Associate Professor of Pharmacology at the University of Milano. She became a Full Professor in 2011. Since 2013 she is Head of the Neuroscience Program at Humanitas, Clinical and Research Center and since 2014 she is Director of the CNR Italian Institute of Neuroscience.
M.Matteoli has been awarded with EMBO and IBRO-MacArthur fellowships. In 2013 she received the Mid-Career Nature Mentoring Award and in 2015 the Atena prize for scientific achievements. Member of the European Molecular Biology Organization (EMBO) and the Academia Europaea due to outstanding scientific achievements. She is part of the international scientific advisory boards of the Paris School of Neuroscience, the Armenise Harvard Foundation, the Center of Psychiatry and Neurosciences of INSERM and Paris-Descartes University, Fondazione Veronesi and Fondazione Volta. She has been a coordinator or partner in several scientific networks, including NATO, HFSP and EC-FP7. Her scientific activity is also funded by Telethon, Cariplo, the Italian Ministry of Health and the Italian Ministry of Education University and Research.
M. Matteoli is in the Editorial Board of many scientific journals and acts as ad hoc reviewer for several international journals including Science, Nature, PNAS, EMBO Journal, Neuron, TINS, Journal of Cell Biology, Journal of Neuroscience. M. Matteoli has authored over 120 research papers and scientific reviews with an average Impact Factor of around 7 and several book chapters. Her H index is 50 (top Italian scientists).

Scientific and Research Interests

Synapses are fundamental brain structures that mediate information transfer between nerve cells; they control all body functions and all aspects of cognition, including attention, perception, learning, decision making, as well as mood and affect. Many psychiatric and neurodegenerative disorders are synaptopathies, i.e. pathological conditions where the molecular and cellular pathways operating at the synapse are dysregulated. Interestingly, inflammation has long-term consequences and could speculatively modify the risk and/or severity of a variety of brain diseases. Whether inflammation cascades impact synapse formation and function is not completely defined, although a number of molecules involved in inflammatory processes have been found to regulate specific neuronal processes.

Michela Matteoli’s lab activity aims at understanding the molecular mechanisms at the basis of synapse dysfunctions in neurodegenerative and psychiatric diseases and at defining how glia-neuron interaction and inflammation impact this process, in order to identify new targets suitable for therapeutic intervention.

 

Selected Publications 

  1. Matteo Tamborini , Erica Locatelli, Marco Rasile  , Ilaria Monaco , Simona Rodighiero , Irene Corradini ,  Mauro Comes Franchini , Lorena Passoni , Michela Matteoli  (2016) A novel approach combining CTX-nanovectors and low dose radiation to reach infiltrating tumor niches in glioblastoma ACS nano in press (IF 12.881)

  2. Joshi P, Turola E, Ruiz A, Bergami A, Libera DD, Benussi L, Giussani P, Magnani G, Comi G, Legname G, Ghidoni R, Furlan R, Matteoli M*, Verderio C. (2014) Microglia convert aggregated amyloid-β into neurotoxic forms through the shedding of microvesicles. (*corresponding) Cell Death Differ. 2014 Apr;21(4):582-93. doi: 10.1038/cdd.2013.180. Epub 2013 Dec 13. (IF 8.385)

  3. (E Menna, S Zambetti, R Morini, Aa Donzelli, D Calvigioni, A Disanza, C, V Cappello, G Fossati, C Regondi, C Frassoni, M Francolini, M Sala, G Scita, M Fahnestock and M Matteoli (2013) Eps8 controls dendritic spine density and synaptic plasticity through its actin-capping activity.. EMBO J 12;32(12):1730-44. (IF 10.748)

  4. Romana Tomasoni, Daniele Repetto, Raffaella Morini, Fabrizio Gardoni, Monica Di Luca, Emilia Turco, Paola Defilippi and Michela Matteoli (2013) SNAP-25 REGULATES SPINE FORMATION THROUGH POSTSYNAPTIC BINDING TO p140Cap. Nature Comm,  19;4:2136. (IF 10.742).

  5. A Senatore, S Colleoni, C Verderio, E Restelli, R Morini, S B. Condliffe, IBertani, S Mantovani, M Canovi, E Micotti, G Forloni, A C. Dolphin, M Matteoli, M Gobbi, and R Chiesa (2012) Mutant Prion Protein Suppresses Glutamatergic Neurotrasmission in Cerebellar Granule Neurons by Impairing Membrane Delivery of Voltage-gated Calcium Channel 2-1 Subunit. Neuron 26;74(2):300-13. (IF 14.03)

Why
Humanitas
University?
An Established Institution

An Established Institution
Humanitas is a renowned healthcare institution that has offered Medical Degrees for well over a decade as a partner of the University of Milan.

An International Career

An International Career
Join our international medical community where classes are taught in English by experienced professors and medical doctors from around the world. Your degree will allow you to work as a MD in the EU and abroad.

Clinical Experience

Clinical Experience
Direct clinical experience is supported by a solid tutoring system and starts in your third year, which gives you considerable practical experience.

Innovative and Active Teaching

Innovative and Active Teaching
Humanitas curriculum is enhanced by a wide variety of active learning methods based on a student-centred approach (Problem-Based Learning, Case method, Concept maps, Simulated patients).

Milano and Italy

Milano and Italy
Enjoy the style, culture, gastronomy and entertainment of one of Europe's most exciting cities. Venture further to experience the delights of Italy or use the opportunity to learn Italian.

Advanced Research and Technology

Advanced Research and Technology
Humanitas can count on state-of-the-art technologies and research experience. A new simulation centre of 1000 sm, designed according to the highest technological standards, will be ready for autumn 2017.

Contact Us

Contact
Humanitas University
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Pieve Emanuele 20090 Milan, Italy

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