Gioacchino Natoli

Full Professor
Biochemistry

E-mail gioacchino.natoli@hunimed.eu 

Biosketch

  • 1991: Medical Doctor with honors, University of Rome, La Sapienza
  • 1991-1996: Residency in Internal Medicine (University of Rome, La Sapienza)
  • 1998-2000: Post-doctoral fellow, University of California San Diego (Prof. Michael Karin)
  • 2000-2005: Principal Investigator, IRB, Bellinzona, Switzerland
  • 2005-: Principal Investigator, IEO, Milan, Italy
  • 2013-: EMBO member
  • 2011+2016: Advanced ERC grants
  • 2016-: Full Professor of Biochemistry, Humanitas University

Scientific and Research Interests

  • Genomics and Next Generation Sequencing Technologies
  • Transcriptional and epigenetic control of inflammation
  • Transcriptional control of pancreatic tumorigenesis

Google Scholar

Students interested in Genomic Technologies and Genomic Medicine are invited to contact me for possible internships and thesis projects.

 

Selected Publications

  1. Transcription of mammalian cis-regulatory elements is restrained by actively enforced early termination (L. M.I. Austenaa, I. Barozzi, M. Simonatto, S. Masella, G. Della Chiara, S. Ghisletti, A. Curina, E. de Wit, B.A.M. Bouwman,  S. de Pretis, V. Piccolo, A. Termanini, E. Prosperini, M. Pelizzola, W. de Laat, and G. Natoli). Molecular Cell 60, 460-474 (2015).
  2. Chromatin contribution to the regulation of immunity (S. Smale, A. Tharakovsky, G. Natoli) Annual Review of Immunology 32: 489-511 (2014).
  3. Latent enhancers activated by stimulation in differentiated cells (Ostuni R, Piccolo V, Barozzi I, Polletti S, Termanini A, Bonifacio S, Curina A, Prosperini E, Ghisletti S, Natoli G.) Cell. 152: 157-71 (2013).
  4. Identification and characterization of enhancers controlling the inflammatory gene expression program in macrophages (S. Ghisletti, I. Barozzi, F. Mietton, S. Polletti, F. De Santa, E. Venturini, L. Gregory, L. Lonie, A. Chew, C.L. Wei, J. Ragoussis, G. Natoli) Immunity, 32:317-28. Epub 2010 Mar 4 (2010).
  5. The histone H3 lysine 27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing (F. De Santa, M.G. Totaro, E. Prosperini, S. Notarbartolo, G. Testa and G. Natoli). Cell 130, 1083-1094 (2007).
Why
Humanitas
University?
An Established Institution

An Established Institution
Humanitas is a renowned healthcare institution that has offered Medical Degrees for well over a decade as a partner of the University of Milan.

An International Career

An International Career
Join our international medical community where classes are taught in English by experienced professors and medical doctors from around the world. Your degree will allow you to work as a MD in the EU and abroad.

Clinical Experience

Clinical Experience
Direct clinical experience is supported by a solid tutoring system and starts in your third year, which gives you considerable practical experience.

Innovative and Active Teaching

Innovative and Active Teaching
Humanitas curriculum is enhanced by a wide variety of active learning methods based on a student-centred approach (Problem-Based Learning, Case method, Concept maps, Simulated patients).

Milano and Italy

Milano and Italy
Enjoy the style, culture, gastronomy and entertainment of one of Europe's most exciting cities. Venture further to experience the delights of Italy or use the opportunity to learn Italian.

Advanced Research and Technology

Advanced Research and Technology
Humanitas can count on state-of-the-art technologies and research experience. A new simulation centre of 1000 sm, designed according to the highest technological standards, will be ready for autumn 2017.

Contact Us

Contact
Humanitas University
Via Rita Levi Montalcini 4,
Pieve Emanuele 20090 Milan, Italy

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By public transport

Go straight on from Porta Ticinese, to Corso San Gottardo, to via Meda, via Montegani, and via dei Missaglia, then follow the signs for Istituto Clinico Humanitas, or Basiglio Milano 3.