Davide Pozzi

Researcher
Pharmacology

Email davide.pozzi@humanitasresearch.it 

Education and Academic Background

Education

  • 2005: PhD in Biotechnology Applied to Medical Sciences, Department of Medical Genetic, University of Milan (Italy).

  • 2001: Master’s degree in Biological Sciences (summa cum laude), Department of Structural and Functional Biology, University of Insubria, Varese (Italy).

Research and Teaching Experience

  • 2017- Assistant professor at Humanitas University HUNIMED, Milan, Italy.
  • Academic years 2015/16; 2016/17 – Basic and Clinical Pharmacology at School of Medicine, Humanitas University.
  • Academic years 2013/14; 2015/16; 2016/17 – Basic and Clinical Pharmacology at School of Nursing, Humanitas University.
  • 2013-2016: Research Scientist, Laboratory of Pharmacology and Brain Pathology, Humanitas Clinical and Research Center, Milan, Italy.
  • 2010-2012: Senior post-doctoral fellow, Neuropsycopharmacology Lab, Department of Neuroscience, DIBIT- San Raffaele Vita-Salute University, Milano, Italy.
  • Academic years 2009/10; 2010/12; 2012/13 – Basic and Clinical Pharmacology at School of Medicine, University of Milan. 
  • Academic years 2009/10; 2010/12; 2012/13 – Basic and Clinical Pharmacology at School of Medicine, Faculty of Biotechnology, San Raffaele Vita-Salute. 
  • 2007-2010: Post-doctoral fellow, Istituto Italiano di Tecnologia, Department of Neuroscience and Brain Technologies, Genova, Italy.
  • 2002-2006: PhD Student, CNR –Istituto di Neuroscienze – Section of Molecular and Cellular Pharmacology, Milano, Italy.
  • 1999- 2001: Graduate student, Department of structural and functional biology, Varese, Italy.

Meeting and Symposia

  • Organizer of the International School of Neuroscience in Como, 18-21 October 2016.
  • Invited speaker at Symposium en marge du Congrès des Neurosciences entitled: Intracellular Trafficking in Neurons” at Montpellier, 19/05/2015.

Scientific and Research Interests

Dr. D. Pozzi’s research field is focused on basic neurobiology, with a specific interest on several aspects of synaptic function and structure, such as neurotransmission, synaptic plasticity and synaptogenesis. During his carrier he investigated the molecular mechanisms underlying the development and function of the presynaptic terminal, both at the structural and functional level. Moreover he also studied the molecular differences between glutamatergic and GABAergic synapses, identifying alternative role of presynaptic proteins specifically expressed at the inhibitory and excitatory terminals. Subsequently, he focused his attention on several aspects of synaptic plasticity, working on the clarification of the molecular determinants involved in homeostatic plasticity. In particular he unveiled a new role of the transcription factor REST/NRSF in the negative regulation of intrinsic excitability through the control of sodium channel gene expression during elevated neuronal activity. More recently he started investigating the contribution of immune molecules (i.e. cytokines) to brain homeostasis both in physiological and pathological states. 

 

Selected publications

  1. “Reduced SNAP-25 alters short term plasticity at developing glutamatergic synapses”  Flavia Antonucci, Irene Corradini, Raffaella Morini, Giuliana Fossati, Elisabetta Menna, Davide Pozzi, Simone Pacioni, Claudia Verderio, Alberto Bacci and Michela Matteoli. EMBO Rep. 2013 Jul;14(7):645-51. 
  2. REST/NRSF-mediated intrinsic homeostasis protects neuronal networks from hyperexcitability”  Pozzi D., Lignani G., Ferrea E., Contestabile A., Paonessa F., D’alessandro R., Lipiello P., Boido D., Meldolesi J., Valtorta F., Benfenati F., Baldelli P. EMBO J.  2013 Nov 13;32(22):2994-3007
  3. Early defects in the development of Mecp2 null embryonic cortex precede the onset of overt RTT symptoms” Francesco Bedogni; Clementina Cobolli Gigli; Davide Pozzi; Riccardo L Rossi; Grazisa Rossetti; Linda Scaramuzza; Massimiliano Pagani; Michela Matteoli; Charlotte Kilstrup-Nielsen; Nicoletta Landsberger. Cereb Cortex. 2015 May
  4. Ectonucleotidase activity and immunosuppression in astrocyte-CD4 T cell bidirectional signaling.” Filipello F, Pozzi D, Proietti M, Romagnani A, Mazzitelli S, Matteoli M, Verderio C, Grassi F. Oncotarget. 2016 Jan 13.
  5. Lack of IL-1R8 in neurons causes hyperactivation of IL-1 receptor pathway and induces MECP2-dependent synaptic defects” Romana Tomasoni, Raffaella Morini, Jose P. Lopez-Atalaya, Irene Corradini, Alice Canzi, Marco Rasile, Cristina Mantovani, Davide Pozzi, Cecilia Garlanda, Alberto Mantovani Elisabetta Menna, Angel  Barco and Michela Matteoli. Elife. 2017 Mar 28;6

 

Grants and Awards

Co-investigator in projects funded by the following agencies:

  • PRIN (2005) Programmi di ricerca cofinanziati;
  • EUSynapse (2004). Integrated Project: From molecules to networks: understanding synaptic physiology and pathology in the brain through mouse models. Code: FP6-2004 LIFESCIHEALTH-5 Integrated Project;
  • ITALIAN FOUNDATION OF MULTIPLE SCLEROSIS (2011). Project title: role of pro- and anti-inflammatory cytokines in the modulation of presynaptic composition and functioning: new perspectives in multiple sclerosis research. Code 2011/R/38;
  • FONDATION JEROME LEJEUME (2011). Project title: Identification and characterization of a missense mutation in the SYN1 gene in a family affected by non-syndromic X-linked mental retardation. Code 953-VF2011B;
  • CARIPLO Foundation (2015). Project title: A systematic molecular study of neuroimmune mechanisms in aging.
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