Cecilia Garlanda

Associate Professor
Clinical Pathology

Head of the Laboratory of Experimental Immunopathology at Humanitas Research Hospital
Teaching appointments: Course of Medical Microbiology

Email cecilia.garlanda@humanitasresearch.it
Phone +39 02 82245115
Site humanitas-research.org/cecilia-garlanda/

Education and Academic Background

  • 1990 Degree in Veterinary Medicine. Università degli Studi di Milano, Milan, Italy.

  • 1991-1994 Research assistant, Immunology Lab, Inst. Ricerche Farmacologiche “Mario Negri“, Milan.

  • 1994-1995 Visiting fellow, Département de Biologie Moléculaire et Structurale- Unité INSERM 217-Centre d’Etudes Nucléaires de Grenoble, France.

  • 1996-2004 Research assistant, and 2004-2005 Unit Head (Experimental Immunopathology) in the Laboratory of Immunology, Istituto di Ricerche Farmacologiche “Mario Negri“, Milan.

  • From Sept 2005 Head of the Laboratory of Experimental Immunopathology in the Dept. of Research in Immunology, Humanitas Clinical and Research Hospital, Rozzano, Milan.

  • From September 2015: Adjunct Professor of Medical Microbiology, Humanitas University.

  • From May 2017: Associate Professor of Clinical Pathology, Humanitas University, Rozzano, Milan.

Scientific and Research Interests

My expertise is related to innate immunity and regulation of inflammatory responses.

My activity has been focused on the functional characterization of original molecules of the immune system, in particular of the long pentraxin PTX3 in innate immune responses to pathogens of fungal, bacterial or viral origin, and in the regulation of inflammatory responses in conditions of infections or tissue damage, such as wound healing and cancer.

I contributed to characterize the diagnostic potential of PTX3 in human inflammatory diseases and I am now involved in the translation of PTX3 to the clinic as therapeutic and diagnostic tool in infectious diseases.

I also focused on IL-1R8/SIGIRR, a member of the family of IL-1 Receptors and Toll Like Receptors, acting as a negative regulator of inflammatory and immune responses triggered by TLR engagement and by IL-1 family members, in the context of inflammatory diseases, infections, autoimmunity and cancer.

 

Selected publications

  1. Garlanda C., Hirsch E., Bozza S., Salustri A., De Acetis M., Nota R., Maccagno A., Riva F., Bottazzi B., Peri G., Doni A., Vago L., Botto M., De Santis R., Carminati P., Siracusa G., Altruda F., Vecchi A., Romani L. and Mantovani A. – Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response. Nature. 420: 182-186, 2002.

  2. Garlanda C., Dinarello C. A. and Mantovani A. – The interleukin-1 family: back to the future. Immunity. 39: 6, 1003-18, 2013. http://www.ncbi.nlm.nih.gov/pubmed/24332029.

  3. Jaillon S., Moalli F., Ragnarsdottir B., Bonavita E., Puthia M., Riva F., Barbati E., Nebuloni M., Cvetko Krajinovic L., Markotic A., Valentino S., Doni A., Tartari S., Graziani G., Montanelli A., Delneste Y., Svanborg C., Garlanda C. and Mantovani A. – The Humoral Pattern Recognition Molecule PTX3 Is a Key Component of Innate Immunity against Urinary Tract Infection. Immunity. 40: 4, 621-32, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24745336.

  4. Bonavita E., Gentile S., Rubino M., Maina V., Papait R., Kunderfranco P., Greco C., Feruglio F., Molgora M., Laface I., Tartari S., Doni A., Pasqualini F., Barbati E., Basso G., Galdiero M. R., Nebuloni M., Roncalli M., Colombo P., Laghi L., Lambris J. D., Jaillon S., Garlanda C.* and Mantovani A*. – PTX3 is an extrinsic oncosuppressor regulating complement-dependent inflammation in cancer. Cell. 160: 4, 700-14, 2015. http://www.ncbi.nlm.nih.gov/pubmed/25679762.

  5. Doni A., Musso T., Morone D., Bastone A., Zambelli V., Sironi M., Castagnoli C., Cambieri I., Stravalaci M., Pasqualini F., Laface I., Valentino S., Tartari S., Ponzetta A., Maina V., Barbieri S. S., Tremoli E., Catapano A. L., Norata G. D., Bottazzi B., Garlanda C. and Mantovani A. – An acidic microenvironment sets the humoral pattern recognition molecule PTX3 in a tissue repair mode. J Exp Med. 212: 6, 905-25, 2015. http://www.ncbi.nlm.nih.gov/pubmed/25964372.

Why
Humanitas
University?
An Established Institution

An Established Institution
Humanitas is a renowned healthcare institution that has offered Medical Degrees for well over a decade as a partner of the University of Milan.

An International Career

An International Career
Join our international medical community where classes are taught in English by experienced professors and medical doctors from around the world. Your degree will allow you to work as a MD in the EU and abroad.

Clinical Experience

Clinical Experience
Direct clinical experience is supported by a solid tutoring system and starts in your third year, which gives you considerable practical experience.

Innovative and Active Teaching

Innovative and Active Teaching
Humanitas curriculum is enhanced by a wide variety of active learning methods based on a student-centred approach (Problem-Based Learning, Case method, Concept maps, Simulated patients).

Milano and Italy

Milano and Italy
Enjoy the style, culture, gastronomy and entertainment of one of Europe's most exciting cities. Venture further to experience the delights of Italy or use the opportunity to learn Italian.

Advanced Research and Technology

Advanced Research and Technology
Humanitas can count on state-of-the-art technologies and research experience. A new simulation centre of 1000 sm, designed according to the highest technological standards, will be ready for autumn 2017.

Contact Us

Contact
Humanitas University
Via Rita Levi Montalcini 4,
Pieve Emanuele 20090 Milan, Italy

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