Ana Lleo De Nalda

Researcher
Internal Medicine 

Attending, Division of Internal Medicine and Hepatology, Dep. of Internal Medicine, Humanitas Clinical and Research Center

E-mail ana.lleo@hunimed.eu 
Telefono +39 02 8224 7231
Sitohumanitas.it/medici/ana-lleo-de-nalda

Education and Academic Background

  • 2010-oggi: Attending, Liver Unit, Dep of Internal Medicine, Humanitas Clinical and Research Center
  • 2010-2014: Post-doctoral researcher, Università degli Studi di Milano.
  • 2006-2010: Research Fellow Division of Rheumatology, Allergy, and Clinical Immunology, Prof. M. Eric Gershwin. University of California – Davis, CA, USA
  • 2009: PhD, Università degli Studi di Milano.
  • 2006: Recidency, Internal Medicine (70/70 e lode). Università degli Studi di Milano
  • 2000: MD degree (110/110 e lode). Università degli Studi di Milano

Scientific and Research Interests

Her main research interests aim to clarifying the pathogenesis of autoimmune liver disease, in particular Primary Biliary Cholangitis (CBP). She described for the first time specific characteristics of epithelial cells in the bile duct, the target of the CBP immune attack, which would seem essential to explain the biliary specificity of CBP, the recurrence of disease after liver transplantation, and the therapeutic success of ursodesoxic acid.

She is a member of the International Study Group for PBC (PBC Global Group), of the International PSC Study Group and the International Autoimmune Hepatitis Network.

 

Selected publications 

  1. LLEO A, Selmi C, Invernizzi P, Podda M, Coppel RL, Mackay IR, Gores GJ, Ansari AA, Van De Water J, Gershwin ME. – Apotopes and the biliary specificity of primary biliary cirrhosis. Hepatology, 2009 Mar;49(3):871-9 ISSN: 0270-9139
  2. LLEO A, Bowlus LC, Yang QX, Invernizzi P, Podda M, Van de Water J, Ansari AA, Coppel RL, Worman HJ, Gores GJ and Gershwin ME. –Biliary apotopes and antimitochondrial antibodies activate innate immune responses in primary biliary cirrhosis. Hepatology 2010; Sep;52(3):987-98.
  3. Liu X, Invernizzi P, Lu Yue, Kosoy R, Lu Yan, Bianchi I, Podda M, Xu C, Xie G, Macciardi F, Selmi C, Lupoli S, Shigeta R, Ransom M, LLEO A, Lee AT, Mason AL, Myers RP, Peltekian KM, Ghent CN, Bernuzzi F, Zuin M, ICPBCG, Gregersen PK, Heathcote EJ, Hirschfield GM, Siminovitch KA, Amos CI, Gershwin ME, and Seldin MF. – Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis. Nature Genetics, 2010 Aug;42(8):658-60
  4. LLEO A, Zhang W, McDonald WH, Seeley EH, Leung PS, Coppel RL, Ansari AA, Adams DH, Afford S, Invernizzi P, Gershwin ME. – Shotgun proteomics: identification of unique protein profiles of apoptotic bodies from biliary epithelial cells. Hepatology. 2014 Oct;60(4): 1314-23
  5. LLEO A, Jepsen P, Morenghi E, Carbone M, Moroni L, Battezzati PM, Podda M, Mackay IR, Gershwin ME, and Invernizzi P – Evolving trends in female to male incidence and male mortality of primary biliary cholangitis. Scientific Reports 2016

 

Academic honors, awards and prizes

  • 2001 Gruppo Italiano per la lotta contro il LES
  • 2009 Fellowship AISF (Associazione Italiana per lo Studio del Fegato) “Prof. Mario Coppo” Mitochondrial apotopes: the key for biliary specificity in primary biliary cirrhosis
  • 2010
    • “L’Oreal per la donna e la Scienza” Award
    • “Young Investigator Award”, A.I.S.F. Monothematic Conference
  • 2011 EASL Sheila Sherlock Short-Term Fellowship
Why
Humanitas
University?
An Established Institution

An Established Institution
Humanitas is a renowned healthcare institution that has offered Medical Degrees for well over a decade as a partner of the University of Milan.

An International Career

An International Career
Join our international medical community where classes are taught in English by experienced professors and medical doctors from around the world. Your degree will allow you to work as a MD in the EU and abroad.

Clinical Experience

Clinical Experience
Direct clinical experience is supported by a solid tutoring system and starts in your third year, which gives you considerable practical experience.

Innovative and Active Teaching

Innovative and Active Teaching
Humanitas curriculum is enhanced by a wide variety of active learning methods based on a student-centred approach (Problem-Based Learning, Case method, Concept maps, Simulated patients).

Milano and Italy

Milano and Italy
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Advanced Research and Technology

Advanced Research and Technology
Humanitas can count on state-of-the-art technologies and research experience. A new simulation centre of 1000 sm, designed according to the highest technological standards, will be ready for autumn 2017.

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