The quantity of data that is currently produced in everyday life and practically in every sector, is...
Luca Di Tommaso
Assistant Professor of Pathology – MED/08
Full pathologist, cytopathology and liver pathology, Humanitas Clinical and Research Center
Fellow of the International Academy of Citology
Phone +39 0282244715
Education and Academic Background
- 1997 M.D., “summa cum laude”, University of Bologna, School of Medicine, Bologna (Italy)
- 2003 Postgraduate Medical School in Pathology, University of Bologna, Bologna (Italy)
- 2014 Fellowship, International Academy of Cytology
- 2004 to 2012: Adjunct Professor of Pathology, University of Milan, School of Medicine, Milan
- 2012 to 09/2015 Assistant Professor of Pathology, University of Milan, School of Medicine, Milan
- 10/2015 to date: Assistant professor of Pathology, Humanitas University, Rozzano, Milan
- 2003 to present: Staff Pathologist, Humanitas Clinical Institute, Rozzano, Milan
- 2012 to present: Head of Section of Liver Pathology, Pathology Unit, Humanitas Clinical Institute.
- 2012 to present: Head of Section of Cytology, Pathology Unit, Humanitas Clinical Institute.
Scientific and Research Interests
In my early studies I investigated the morphological, phenotypical and molecular aspects of human hepato-carcinogenesis (and in particular those of pre- and early- neoplastic lesions). I then moved to the study of prognostic features of more advanced forms of hepato- and cholangio- cellular carcinoma (Primary Liver Cancer, PLC). All the above researches were focused on tumoral cells. More recently, I focused my attention on the study of tumoral microenvironment in PLC and in liver metastases. Other fields of interest are represented by Breast, Thymic and Thyroid pathology: in each of these field I contributed to identify novel entities (such as the adenoid cystic variant of Thymic carcinoma as well as a strong commitment for History of Medicine).
The goal of my research was and still is the identification and set up of diagnostic, prognostic and predictive markers. Along this line, I recently developed a strong interest in the field of digital-, computational- and augmented- pathology. These, which taken as a whole go under the definition of e-Pathology, best represent the future scenario of my research and possibly its most relevant translational aspects.
- Di Tommaso L, Franchi G, Park NY, Fiamengo B, Destro A, Morenghi E, Montorsi M, Torzilli G, Tommasini M, Terracciano L, Tornillo L, Vecchione R, Roncalli M. Diagnostic value of HSP70, glypican 3 and glutamine synthetase in hepatocellular nodules in cirrhosis. Hepatology 2007; 45(3): 725-735
- Di Tommaso L, Destro A, Seok JY, Balladore E, Terracciano L, Sangiovanni A, Iavarone M, Colombo M, Jang JJ, Yu E, Jin SY, marenghi M, Park YN, Roncalli M The application of a panel of markers (hsp 70, gpc3, gs) in liver biopsies is useful for HCC detection. Journal of Hepatology 2009; 50(4): 746-54
- Nault JC, Calderaro J, Di Tommaso L, Balabaud C, Zafrani ES, Bioulac-Sage P, Roncalli M, Zucman-Rossi J. TERT promoter mutation is an early somatic genetic alteration in the transformation of premalignant nodules in hepatocellular carcinoma on cirrhosis. Hepatology, 2014; 60(6):1983-92
- Renne SL, Woo HY, Allegra A, Rudini N, Yano H, Donadon M, Viganò L, Akiba J, Lee HS, Rhee H, Park YN, Roncalli M, Di Tommaso L. VETC (vessels encapsulating tumor clusters) is a powerful predictor of aggressive hepatocellular carcinoma. Hepatology. 2019 Jun 17. doi: 10.1002/hep.30814.
- Huang YT, Renne SL, Sollai M, Damiani D, Bossi P, Morenghi E, Roncalli M, Di Tommaso L. Clinical Application of a Real-Time Telepathology System for Frozen Section Diagnosis in Comparison With Optical Microscope. Frontiers in Medicine 2019; 6: 215. doi:10.3389/fmed.2019.00215