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Full Professor of Cardiology MED/11
Head, Department of Cardiovascular Medicine, and Director of Cardiovascular Research at Humanitas Research Hospital
Director Milan Unit, Institute of Genetics and Biomedical Research (IRGB), National Research Council of Italy.
Honorary Professor, Chair in Molecular Cardiology, University of Leicester, UK
Phone + 390282244635
Dr. Gianluigi Condorelli is professor of cardiology, director of the post-graduate school of cardiology at Humanitas University, Milan, and head of the Department of Cardiovascular Medicine and of cardiovascular research at the Humanitas Research Hospital. He graduated cum laude in Medicine at the University “Federico II”, Naples, Italy, in 1989 and received a PhD in Cardiovascular Sciences from the University “Tor Vergata”, Rome, in 1993; he is a practicing cardiologist who trained in molecular cardiology at Harvard University, Boston, and in molecular oncology at Thomas Jefferson University, Philadelphia; he has been faculty at Thomas Jefferson University and at the University of California San Diego, La Jolla and director of the Department of Medicine, National Research Council of Italy. His research has been funded by grants from international agencies such the NHLBI-NIH USA, the European Union, the European Research Council (Advanced grant), the Fondation LeDucq and other relevant national ones.
Scientific and Research Interests
Dr Condorelli’s work focuses on the molecular mechanisms of cardiovascular diseases, in particular heart failure, studying the role of non-coding RNAs and epigenetics in this disease. Other lines of research are related to the understanding of the mechanisms of cardiomyopathies (by means of genetics and iPSCs), to the identification of biomarkers of cardiovascular diseases and, more recently, to the understanding of the role of innate and acquired immunity in cardiovascular diseases.
- Condorelli, G., Drusco, A., Stassi, G., Roncarati, R., Iaccarino, G., Russo, M.A., Gu, Y., Chung, C., Latronico, M., Napoli, C., Sadoshima, J., Croce, C.M., and Ross, J., jr. (2002): Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice. Proc. Natl. Acad. Sci. USA, 99: 12333-8
- Carè, A., Catalucci, D., Felicetti, F., Bonci, D., Ruiz-Lozano, P., Gallo, P., Segnalini, P., Bang, M.L., Dorn, G.W.2nd, Ellingsen, O., Croce, C.M., Peschle, C., and Condorelli, G.(2007): MicroRNA-133 controls cardiac myocyte hypertrophy. Nature Medicine, 13(5):613-8.
- Zhang, D.H., Latronico, M.V.G., Zhang, J.L., Contu, R., Rizzi, R., Catalucci, D., Peterson, K.L., Brown, J.H., Chen, J, Sonenberg, N. and Condorelli G. (2010): mTORC-1 regulates cardiac function and myocyte survival through 4E-BP-1 inhibition. The Journal of Clinical Investigation, 120(8):2805-16
- Greco CM, Kunderfranco, P., Rubino, M., Larcher, V., Carullo, P., Anselmo, A., Kurz, K., Carell, T., Angius, A., Latronico, MiVG, Papait, R., and Condorelli G (2016) DNA Hydroxymethylation controls cardiomyocyte gene expression in development and hypertrophy Nature Comm, 7:12418. doi: 10.1038/ncomms12418
- Kallikourdis M, Martini E, Carullo P, Sardi C, Roselli G, Greco CM, Vignali D, Riva, F, Ormbostad Berre AM, Stolen TO, Fumero A, Faggian G, Di Pasquale E, Elia L, Rumio C, Catalucci D, Papait R, Condorelli G: T cell costimulation blockade blunts pressure overload-induced heart failure: Nature Comm, 8:14680
- P.I., National Institutes of Health, NHLBI, USA: Role of mTOR, a component of the AKT pathway, in regulating cardiac function (2011-15).
- P.I. European Research Council Advanced Grant: Epigenetics and microRNAs in Myocardial Function and Disease (2012-17).
- Supervisor, Marie Curie Outgoing Fellowship, recipient Paola Cattaneo, PhD (to UCSD).
- Supervisor, Marie Curie Incoming Fellowship, recipient Michelle Monansky, PhD (from U. Illinois).
- ERC Proof of Concept, PI.